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| | Sulfadimethoxine Chemical Properties |
| Melting point | 200 °C | | Boiling point | 265.5°C (rough estimate) | | density | 1.4006 (rough estimate) | | refractive index | 1.6270 (estimate) | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | solubility | NH4OH 1 M: 50 mg/mL, clear, faintly yellow | | pka | pKa 5.94(H2O
t = 25.0±0.5
I = 0.2) (Uncertain) | | form | neat | | color | White to Off-White | | Water Solubility | 46.3mg/L(37 ºC) | | Merck | 14,8905 | | BRN | 306856 | | CAS DataBase Reference | 122-11-2(CAS DataBase Reference) | | EPA Substance Registry System | Sulfadimethoxine (122-11-2) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38-43 | | Safety Statements | 26-36/37-24/25-23 | | RIDADR | 3249 | | WGK Germany | 3 | | RTECS | WO9030000 | | F | 8 | | HazardClass | 6.1(b) | | PackingGroup | III | | HS Code | 29350090 | | Toxicity | LD50 orally in mice: >10 g/kg (Seki) |
| | Sulfadimethoxine Usage And Synthesis |
| Brand Name(s) in US | Albon, Bactrovet, and generic
| | Chemical Properties | White Solid | | Originator | Madribon,Roche,US,1958 | | Uses | Antibacterial.This compound is a contaminant of emerging concern (CECs). | | Definition | ChEBI: A sulfonamide consisting of pyrimidine having methoxy substituents at the 2- and 6-positions and a 4-aminobenzenesulfonamido group at the 4-position. | | Manufacturing Process | 1.4 g of 4-phenylsulfonyl-2,6-dimethoxypyrimidine and 4 g of sodium
sulfanilamide (both dried over potassium hydroxide) were very finely ground
and heated in an oil bath for 10 hours at 120°C (inside temperature). The
reaction mixture was taken up in 30 ml of water and treated with 3 ml of 2 N
sodium hydroxide solution. After standing for one hour at 0°C, the turbid
solution was filtered and the filtrate was made alkaline with sodium carbonate.
After again standing for one hour at 0°C, the precipitate was filtered off (1.9 g
of regenerated sulfanilamide) and the filtrate was neutralized with acetic acid,
whereupon crystallization resulted. The isolated crystals of 4-sulfanilamido-
2,6-dimethoxypyrimidine weighed 1.3 g (84% of theory), melting point 190°C
to 196°C. | | Therapeutic Function | Antibacterial | | Pharmaceutical Applications | 2,4-Dimethoxy-6-sulfanilamido-1,3-diazine. A rapidly absorbed
compound with a long half-life (38–40 h) and a high degree of
protein binding (98%). Renal clearance is very slow, and daily
dosage maintains adequate plasma levels. | | Safety Profile | Moderately toxic by intraperitoneal, intravenous, and subcutaneous routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of SOx and NOx. | | Veterinary Drugs and Treatments | Sulfadimethoxine injection and tablets are approved for use in dogs
and cats for respiratory, genitourinary, enteric and soft tissue infections
caused by susceptible organisms. Sulfadimethoxine is used in
the treatment of coccidiosis in dogs although not approved for this
indication.
In horses, sulfadimethoxine injection is approved for the treatment
of respiratory infections caused by Streptococcus equi.
In cattle, the drug is approved for treating shipping fever complex,
calf diphtheria, bacterial pneumonia and foot rot caused by
susceptible organisms.
In poultry, sulfadimethoxine is added to drinking water to treat
coccidiosis, fowl cholera, and infectious coryza. |
| | Sulfadimethoxine Preparation Products And Raw materials |
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