ChemicalBook Product Catalog Pharmaceutical intermediates Heterocyclic compound Thiophene compounds 2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE

2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE

2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE Basic information
Product Name:2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE
Synonyms:2-amino-4,5,6,7-tetrahydrobenzothiophene-3-carboxamide;2-azanyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide;2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide(SALTDATA: FREE);Benzo[b]thiophene-3-carboxaMide, 2-aMino-4,5,6,7-tetrahydro-;2-Amino-4,5,6,7-tetrahydro-1-benzo[b]thiophene-3-carboxamide;TIMTEC-BB SBB000354;2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE;AKOS MSC-0467
CAS:4815-28-5
MF:C9H12N2OS
MW:196.27
EINECS:
Product Categories:Sulphur Derivatives
Mol File:4815-28-5.mol
2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE Structure
2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE Chemical Properties
Melting point 195-197℃
Boiling point 332.5±42.0 °C(Predicted)
density 1.337±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
pka15.70±0.20(Predicted)
CAS DataBase Reference4815-28-5(CAS DataBase Reference)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 22
HazardClass IRRITANT
MSDS Information
2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE Usage And Synthesis
HazardCauses skin irritation. Causes serious eye irritation. May cause respiratory irritation.
SynthesisThe synthesis of 2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE is as follows:
A solution of aminothiophene EO (prepared as described in Example C; 500mg, 2.8 mmol) in concentrated sulphuric acid (5ml) was stirred at room temperature for 65 hours. The reaction mixture was poured cautiously into ice-cold aqueous potassium carbonate, diluted with water and extracted with ethyl acetate. The combined organic extracts were washed with water and brine, dried over magnesium sulphate and evaporated to dryness under reduced pressure to give the desired product (383mg, 70%) as an off-white solid. 
synthesis of 2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE.png
2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE Preparation Products And Raw materials
Preparation Products5-(3-hydroxyphenyl)-8-thia-4,6-diazatricyclo[7.4.0.0,2,7]trideca-1(9),2(7),5-trien-3-one-->5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D][1,2,3]TRIAZIN-4(3H)-ONE
AKOS BBS-00007197 BUTTPARK 25\07-05 AURORA 3750 3-ETHYL-2-MERCAPTO-5,6,7,8-TETRAHYDRO-3H-BENZO[4,5]THIENO[2,3-D]PYRIMIDIN-4-ONE 2-(2-CHLORO-ACETYLAMINO)-4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID AMIDE AKOS BBS-00007201 AKOS 90535 AKOS 94116 3-CYCLOHEXYL-2-MERCAPTO-5,6,7,8-TETRAHYDRO-3H-BENZO[4,5]THIENO[2,3-D]PYRIMIDIN-4-ONE (1)benzothieno(2,3-d)pyrimidin-4(1h)-one,2,3,5,6,7,8-hexahydro-3-methyl-2-thio AURORA 1747 AKOS 93050 AKOS BBS-00007193 AKOS 94123 2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE AKOS BBS-00007188 (1)Benzothieno(2,3-d)pyrimidin-4(3H)-one, 5,6,7,8-tetrahydro-3-amino-2 -(phenylamino)- AKOS 93017
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