Vadadustat

Vadadustat Basic information

Product Name:	Vadadustat
Synonyms:	Vadadustat;AKB-6548; AKB 6548; AKB6548; PG-1016548; PG 1016548; PG1016548; B-506; B506; VADADUSTAT;PG-1016548;AKB-6548;Vadadustat(AKB-6548/PG-1016548);Vadadustat (AKB-6548);AKB-6548;PG 1016548;PG1016548
CAS:	1000025-07-9
MF:	C14H11ClN2O4
MW:	306.7
EINECS:
Product Categories:	API
Mol File:	1000025-07-9.mol

Vadadustat Chemical Properties

Melting point	172-174°C
Boiling point	674.6±55.0 °C(Predicted)
density	1.461±0.06 g/cm3(Predicted)
storage temp.	Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	4.09±0.40(Predicted)
color	Pale Beige to Light Beige
Stability:	Hygroscopic

Safety Information

MSDS Information

Vadadustat Usage And Synthesis

Description	Vadadustat is an inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) and HIF-PH3 (IC₅₀s = 1.1 and 0.39 micromolar, respectively). It stabilizes HIF-1α in mouse hepatocyte nuclear extracts. Vadadustat (50 and 100 mg/kg) increases erythropoietin levels in mouse serum.
Uses	Vadadustat is a novel HIF (Hypoxia-inducible factor) stabilizer. It provides an effective anemia treatment in nondialysis-dependent chronic kidney disease.

Vadadustat Preparation Products And Raw materials

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