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| | Todralazine hydrochloride Basic information |
| Product Name: | Todralazine hydrochloride | | Synonyms: | apirachol;binazin;binazine;carbazicacid,3-(1-phthalazinyl)-,ethylester,monohydrochloride;hydrazinecarboxylicacid,2-(1-phthalazinyl)-,ethylester,monohydrochloride;TODRALAZINE HYDROCHLORIDE;2-(1-PHTHALAZINYL)-HYDRAZINECARBOXYLIC ACID ETHYL ESTER HYDROCHLORIDE;ethyl 3-(phthalazin-1-yl)carbazate hydrochloride | | CAS: | 3778-76-5 | | MF: | C11H13ClN4O2 | | MW: | 268.7 | | EINECS: | | | Product Categories: | | | Mol File: | 3778-76-5.mol |  |
| | Todralazine hydrochloride Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 5 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): slightly | | form | A crystalline solid |
| Hazard Codes | Xn | | Risk Statements | 20/21/22 | | Safety Statements | 36 | | WGK Germany | 3 | | RTECS | FE2778600 | | Toxicity | LD50 i.p. in mice: 500 mg/kg (Parravincini) |
| | Todralazine hydrochloride Usage And Synthesis |
| Originator | Prorazin,Teisan | | Uses | Antihypertensor | | Uses | Todralazine Hydrochloride is an antihypertensive agent for research use. Vasodilator. | | Manufacturing Process | A suspension of 13 g of hydrazinophthalazine in 500 ml of anhydrous ethanol
is cooled, under agitation to a temperature of -10°C. To the suspension is
added dropwise within 30 min a solution of 4.5 g of ethyl chlorocarbonate in
150 ml of anhydrous ethanol and the reaction mass is agitated for about 2
hours, maintaining a temperature of -10°C. The temperature is then raised to
about 20°C and stirring is continued for 2 hours, whereupon heating is applied
and boiling is maintained for 15 min. After cooling, the separated 1-
hydrazinophthalazine hydrochloride is filtered and washed with anhydrous
ethanol.
The filtrate is evaporated to a dry state under decreased pressure at a
temperature of below 50°C. The residue in a quantity of 8.5 g is dissolved in a
boiling solution of 3 ml of concentrated hydrochloric acid in 15 ml of water,
and after adding 5 ml of 90%-ethanol the solution is cooled to a temperature
of below 0°C.
The separated 1-carboethoxyhydrazinophthalazine hydrochloride is filtered and
washed with anhydrous ethanol. 11.5 g of a raw product are obtained which
for the purpose of purification are dissolved in 15 ml of boiling water with an
addition of 10 ml of 96%-ethanol and after cooling to below 0°C, the pure 1-
carboethoxyhydrazinophthalazine hydrochloride is filtered. 9.8 g of the are
obtained.
| | Therapeutic Function | Antihypertensive |
| | Todralazine hydrochloride Preparation Products And Raw materials |
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