ChemicalBook Product Catalog Biochemical Engineering Polypeptide ALPHA-CGRP (8-37) (HUMAN)

ALPHA-CGRP (8-37) (HUMAN)

ALPHA-CGRP (8-37) (HUMAN) Basic information
Product Name:ALPHA-CGRP (8-37) (HUMAN)
Synonyms:calcitoningene-relatedpeptide(8-37;VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASN-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-LYS-ALA-PHE-NH2;calcitonin gene related peptide*fragment 8-37 hum;A-CGRP (8-37) (HUMAN);α-cgrp 8-37;ALA-CYS-ASN-THR-ALA-THR-CYS-VAL-THR-HIS-ARG-LEU-ALA-ASP-PHE-LEU-SER-ARG-SER-GLY-GLY-VAL-GLY-LYS-ASN-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-LYS-ALA-PHE-NH2: ACNTATCVTHRLADFLSRSGGVGKNNFVPTNVGSKAF-NH2DISULFIDE BRIDGE CYS2-CYS7;8-Val-37-Phe-calcitonin gene-related peptide;alpha-Calcitonin gene-related peptide (human reduced), 1-de-L-alanine-2-de-L-cysteine-3-de-L-aspartic acid-4-de-L-threonine-5-de-L-alanine-6-de-L-threonine-7-de-L-cysteine-
CAS:119911-68-1
MF:C139H230N44O38
MW:3125.59
EINECS:232-693-2
Product Categories:Peptide;Calcitonin and CGRP receptor
Mol File:119911-68-1.mol
ALPHA-CGRP (8-37) (HUMAN) Structure
ALPHA-CGRP (8-37) (HUMAN) Chemical Properties
density 1.46±0.1 g/cm3(Predicted)
storage temp. -20°C
form powder
Water Solubility Soluble to 0.50 mg/ml in sterile water
Safety Information
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
ALPHA-CGRP (8-37) (HUMAN) Usage And Synthesis
UsesCalcitonin Gene Related Peptide Fragment 8-37 human has been used in the administration of drugs. It has been used to test the hypothesis that calcitonin gene‐related peptide (CGRP) plays a role in the fetal cardiovascular and metabolic defense responses to acute hypoxaemia by affecting sympathetic outflow.
General DescriptionCalcitonin-related peptide α (CALCA) is a 37-amino-acid vasoactive neuropeptide. It is scattered in the central and peripheral nervous systems. The calcitonin/calcitonin gene-related peptide gene complex codes for a small family of peptides: calcitonin, katacalcin and CALCA. This vasodilator is potent than other vasodilators, such as adenosine, substance P or acetylcholine. CALCA gene is located on human chromosome 11p15.2-p15.1. Procalcitonin (PCT) is a calcitonin (CT) precursor.
Biochem/physiol ActionsSelective competitive antagonist at CGRP receptors, but not at calcitonin receptors.Calcitonin gene-related peptide (CALCA) serves as a proangiogenic growth factor in the development of human placenta. Mutations of CALCA gene is associated with Parkinson′s disease, ovarian cancer and essential hypertension. CALCA induce vascular endothelial cell proliferation, migration and capillary-like tube formation.
storageStore at -20°C
ALPHA-CGRP (8-37) (HUMAN) Preparation Products And Raw materials
Serotonin hydrochloride ALPHA-CGRP (RAT) CALCITONIN (PORCINE) 2-Ethylhexyl mercaptoacetate Sumatriptan Superoxide dismutase DNAK N-(Carboxymethyl)-N-(phosphonomethyl)-glycine Luteolin Calcitonin Gene Related Peptide, chicken CALCITONIN, HUMAN VIP 9-L-Leucine-1-9-kallidin ALPHA-CACINTONIN GENE RELATED PEPTIDE, HUMAN Calcitonin ALPHA-CGRP (8-37) (HUMAN) AC-ALPHA-CGRP (19-37) (HUMAN),ACETYL-ALPHA-CGRP (19-37) (HUMAN) ALPHA-CGRP (23-37) (HUMAN)
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