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| | (+)-AEROPLYSININ-1 Basic information |
| Product Name: | (+)-AEROPLYSININ-1 | | Synonyms: | (+)-aeroplysinini;(1s-trans)-3,5-dibromo-1,6-dihydroxy-4-methoxy-2,4-cyclohexadiene-1-acetonit;4-cyclohexadiene-1-acetonitrile,3,5-dibromo-1,6-dihydroxy-4-methoxy-(1s-tr;aeroplysinini;AEROPLYSININ;(+)-AEROPLYSININ-1;(+)-AEROPLYSININ-1, APLYSINA AEROPHOBA;AEROPLYSININ, APLYSINA AEROPHOBA | | CAS: | 28656-91-9 | | MF: | C9H9Br2NO3 | | MW: | 338.98 | | EINECS: | | | Product Categories: | | | Mol File: | 28656-91-9.mol |  |
| | (+)-AEROPLYSININ-1 Chemical Properties |
| Boiling point | 479.6±45.0 °C(Predicted) | | density | 2.01±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Methanol: Soluble | | form | A solid | | pka | 10.54±0.70(Predicted) |
| | (+)-AEROPLYSININ-1 Usage And Synthesis |
| Description | (+)-Aeroplysinin-1 is a metabolite originally isolated from the marine sponge V. aerophoba with diverse biological activities. (+)-Aeroplysinin-1 (0.25-0.5 μM) induces cell death in MCF-7 and ZR-75-1 human breast cancer cells in a time- and concentration-dependent manner but has no effect on normal human fibroblasts at concentrations up to 5 μM. It also blocks EGF-induced endocytosis of the EGF receptor (EGFR) and EGF-dependent cell proliferation in MCF-7 cells. (+)-Aeroplysinin-1 inhibits bovine aortic endothelial (BAE) cell proliferation and cord formation in a Matrigel™ assay. It inhibits angiogenesis in a dose-dependent manner in a chick chorioallantoic membrane (CAM) assay when administered from 1.5 to 3 nmol per egg. (+)-Aeroplysinin-1 also has antibacterial activity against Gram-positive bacteria, including S. aureus, S. albus, and B. subtilis, but not Gram-negative bacteria and inhibits HIV-1 replication (IC50 = 14.6 μM) via inhibition of HIV-1 reverse transcriptase. | | Uses | (+)shy-Aeroplysinin-1 is a compound that is an inhibitor of EGFR kinase. | | Definition | ChEBI: Aeroplysinin 1 is a tertiary alcohol. |
| | (+)-AEROPLYSININ-1 Preparation Products And Raw materials |
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