| | ANTIMYCIN A Basic information |
| | ANTIMYCIN A Chemical Properties |
| Melting point | 141-142℃ | | Boiling point | 598.78°C (rough estimate) | | density | 1.6009 (rough estimate) | | refractive index | 1.5800 (estimate) | | storage temp. | 2-8°C | | solubility | Ethanol: soluble | | form | White to faint yellow powder. | | Water Solubility | Soluble in 100% ethanol. Insoluble in water. | | Sensitive | Light Sensitive | | Stability: | Light Sensitive | | EPA Substance Registry System | Antimycin A (1397-94-0) |
| | ANTIMYCIN A Usage And Synthesis |
| Chemical Properties | Antimycin (A3C26H36N2O9) and (Antimycin
A1) C28H40N2O9 are crystalline solids. | | Uses | antifungal, antiviral, interferes in cytochrome oxidation | | Uses | Antimycin A is a complex of related macrocyclic lactones, predominantly A1 to A4, isolated from several species of Streptomyces, first reported in the early 1950s for potent antifungal activity. There are over 20 known analogues in the antimycin A class, mostly involving variation of the fatty acid ester chain length or adjacent alkyl starting unit. Antimycin A binds to cytochrome C reductase at the Qi site, inhibiting the oxidation of ubiquinol to ubiquinone. Antimycin A is widely used as a bioprobe of respiration and other applications with over 5,000 literature citations. | | Uses | Antimycin A is used to study the specific sites of reactive oxygen species production in mitochondria isolated from skeletal muscle of chronic obstructive pulmonary disease patients, and its relationship with local oxidative stress induced by exercise. | | Definition | ChEBI: Antimycin A is a nine-membered bis-lactone having methyl substituents at the 2- and 6-positions, an n-hexyl substituent at the 8-position, an acyloxy substituent at the 7-position and an aroylamido substituent at the 3-position. It is produced by Streptomyces bacteria and has found commercial use as a fish poison. It has a role as a piscicide, a mitochondrial respiratory-chain inhibitor and an antifungal agent. It is a macrodiolide, a member of formamides, a member of benzamides and a member of phenols. | | General Description | Solid. Specific uses for ANTIMYCIN A were not found. ANTIMYCIN A1,and ANTIMYCIN A3 are reported as antibiotics produced by Streptomyces for use as a fungicide and possibly as an insecticide and miticide. Registered only as a pesticide in the U.S. | | Fire Hazard | When heated to decomposition, ANTIMYCIN A emits toxic fumes of oxides of nitrogen. | | Agricultural Uses | Fungicide, Piscicide: A U.S. EPA restricted Use Pesticide (RUP). May
also be used as an insecticide. | | Trade name | FINTROL®; VIROSIN® | | Safety Profile | Poison by ingestion,intraperitoneal, subcutaneous, and intravenous routes.When heated to decomposition it emits toxic fumes ofNOx. | | Potential Exposure | Specific uses for antimycin A were
not found, however, antimycin A1, and antimycin A3 are
reported to be antibiotic substances produced by streptomyces
for use as a fungicide, possible insecticide and miticide.
Registered as a pesticide in the U.S. | | Shipping | UN2811 Toxic solids, organic, n.o.s., Hazard
Class: 6.1; Labels: 6.1-Poisonous materials, Technical
Name Required. |
| | ANTIMYCIN A Preparation Products And Raw materials |
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