ChemicalBook Product Catalog Biochemical Engineering Inhibitors Epigenetics Histone Demethylase inhibitors ML234

ML234

ML234 Basic information
Product Name:ML234
Synonyms:ML234;ML324;ML243;N-[3-(Dimethylamino)propyl]-4-(8-hydroxy-6-quinolinyl)benzamide;NCGC00183808-01;ML324(CID-44143209);CS-2198;ML-324;ML324;ML 324
CAS:1222800-79-4
MF:C21H23N3O2
MW:349.43
EINECS:
Product Categories:Inhibitors
Mol File:1222800-79-4.mol
ML234 Structure
ML234 Chemical Properties
Melting point >187oC (dec.)
Boiling point 590.1±50.0 °C(Predicted)
density 1.188±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,2-8°C
solubility DMSO: soluble10mg/mL, clear
pka4.71±0.40(Predicted)
form powder
color white to light brown
Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Safety Information
Hazard Codes Xn
Risk Statements 22
WGK Germany 3
MSDS Information
ML234 Usage And Synthesis
DescriptionML324 (1222800-79-4) inhibits JMJD2 histone demethylases. Represses the expression of viral (HCMV and HSV-1) immediate early genes (IC50 ~ 10 μM) and abrogates infection. ML-324 represses the reactivation of HSV from the latent state in sensory neurons.1
UsesML324 is a JMJD2 demethylase inhibitor. It blocks the initiation of viral lytic infection and HSV-1 reactivation in the sensory ganglia of latently infected mice.
References1) Liang?et al. (2013),?Targeting the JMJD2 histone demethylases to epigenetically control herpesvirus infection and reactivation from latency; Sci. Transl. Med.,?5?167ra5
ML234 Preparation Products And Raw materials
BEZ235 (NVP-BEZ235, Dactolisib) Olaparib ML216 ML264 PTP1B-IN-2 ML-327 N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine ML213 Birinapant [4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone ML418 ML188 VU0456810 ML364 ML329 ABT 737 VE-821 QNZ (EVP4593)
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