MICROCYSTIN YR

MICROCYSTIN YR Basic information
Product Name:MICROCYSTIN YR
Synonyms:MICROCYSTIN YR;microcystin yr from microcystis aeruginosa;MICROCYSTIN-YR SOLUTION;Cyanoginosin la, 3-L-tyrosine-5-L-arginine;Cyanoginosin la, 3-L-tyrosyl-5-L-arginine;Cyanoginosin la, 3-tyrosyl-5-arginine-;Cyanoginosin yr;Cyanoginosin-yr
CAS:101064-48-6
MF:C52H72N10O13
MW:1045.19
EINECS:621-458-3
Product Categories:Cyanobacterial ToxinsTyrosine Phosphatase Biology;Protein Phosphatase 2 (PP2);Tyrosine Phosphatase Inhibitors;Application Index;Cell Signaling Enzymes;Natural Products
Mol File:101064-48-6.mol
MICROCYSTIN YR Structure
MICROCYSTIN YR Chemical Properties
density 1.33±0.1 g/cm3(Predicted)
Fp 11 °C
storage temp. −20°C
solubility methanol: 2  mg/mL (further dilute to 10% (v/v) methanol)
form white powder
pka3.02±0.70(Predicted)
EPA Substance Registry SystemCyclo[2,3-didehydro-N-methylalanyl-D-alanyl-L-tyrosyl-(3S)-3-methyl-D-.beta.-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-.gamma.-glutamyl] (101064-48-6)
Safety Information
Hazard Codes T+,T,F
Risk Statements 26/27/28-36/37/38-43-39/23/24/25-23/24/25-11
Safety Statements 26-36/37/39-45-36/37-16-7
RIDADR UN 2811 6.1/PG 1
WGK Germany 3
RTECS 000000030272
MSDS Information
ProviderLanguage
SigmaAldrich English
MICROCYSTIN YR Usage And Synthesis
UsesMicrocystin YR from Microcystis aeruginosa has been used to assess cytotoxicity in neutrophils using DNA fragmentation and cell viability assays and as a reference standard in the quantification of microcystin from water samples.
General DescriptionMicrocystin is a potent cyanotoxin produced by the bloom of Microcystis aeruginosa. It is harmful to aquatic animals. It is a heptapeptide and exists as multiple variant forms. pCO2 and nitrogen levels modulate the toxic variants levels. It elicits damage to the liver and other organs.
Biochem/physiol ActionsMicrocystin YR inhibits protein phosphatase type 2A and protein phosphatase type 1. Toxicity to undifferentiated cells was seen by inhibition of neutral red uptake, >80% at 100 μM, after 48 h.
MICROCYSTIN YR Preparation Products And Raw materials
OKADAIC ACID OKADAIC ACID AMMONIUM SALT TAUTOMYCIN NODULARIN SPIRULINA POWDER Microcystin-YR, Microcystis aeruginosa H-BETA-ALA-D-ALA-OH (R)-2-AMINO-N-METHYL-SUCCINAMIC ACID D-2,4-Diaminobutyric acid H-GLY-BETA-ALA-GLY-OH Nalpha-Acetyl-D-asparagine D-Glutamine D-Theanine D-(-)-Asparagine monohydrate N,N'-BIS(3-AMINOPROPYL)ETHYLENEDIAMINE GLYCYL-D-ASPARAGINE MICROCYSTIN YR N-ISOBUTYRYLGLYCINE

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