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| | Trimethyl orthobutyrate Basic information |
| | Trimethyl orthobutyrate Chemical Properties |
| Boiling point | 145-147 °C (lit.) | | density | 0.926 g/mL at 25 °C (lit.) | | refractive index | 1.402-1.404 | | Fp | 50 °C | | storage temp. | Flammables area | | solubility | Chloroform, Ethyl Acetate | | form | Liquid | | Specific Gravity | 0.926 | | color | Clear colorless to slightly yellow | | BRN | 1737319 | | CAS DataBase Reference | 43083-12-1(CAS DataBase Reference) | | NIST Chemistry Reference | Trimethyl orthobutyrate(43083-12-1) |
| Provider | Language |
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ACROS
| English |
| | Trimethyl orthobutyrate Usage And Synthesis |
| Chemical Properties | Clear colorless to slightly yellow liquid | | Uses | Trimethyl orthobutyrate has been used in the preparation of:
- 5-acetamido-9-O-butyroyl-3,5-dideoxy-D-glycero-2-nonulo pyranosonic acid
- 9-O-butyroyl-3,5-dideoxy-5-glycoloylamido-D-glycero-2-nonulo pyranosonic acid
| | Uses | Trimethyl orthobutyrate can be used for:
- Acylation at OH-9 of N-acetylneuraminic acid and N-glycoloylneuraminic acid to give the corresponding 9-O-acylated derivatives.
- Conversion of 2-amino-N-(1-H-benzimidazol-2-yl)benzamide to 2-propyl-3-benzimidazolyl-4(3H)-quinazolinone.
- Preparation of 2-propyl substituted benzimidazoles from 1,2-benzenediamines.
It can also be used in the total synthesis of dl-camptothecin, Olmesartan Medoxomil, DE and CDE ring analogs of camptothecin, and homologs of 1,25-dihydroxyvitamin D3. | | General Description | Kinetics and mechanism of gas-phase elimination of trimethyl orthobutyrate has been examined over the temperature range of 310-369°C and pressure range of 50-130Torr. |
| | Trimethyl orthobutyrate Preparation Products And Raw materials |
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