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| | CAY10683 (SantacruzaMate A) Basic information |
| Product Name: | CAY10683 (SantacruzaMate A) | | Synonyms: | CAY10683 (SantacruzaMate A);ETHYL 4-OXO-4-(PHENETHYLAMINO)BUTYLCARBAMATE;N-[4-oxo-4-[(2-phenylethyl)amino]butyl]-carbamic acid ethyl ester;Santacruzamate A (CAY10683);SantacruzaMate A;CAY10683;CAY1083;Carbamic acid, N-[4-oxo-4-[(2-phenylethyl)amino]butyl]-, ethyl ester | | CAS: | 1477949-42-0 | | MF: | C15H22N2O3 | | MW: | 278.35 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 1477949-42-0.mol |  |
| | CAY10683 (SantacruzaMate A) Chemical Properties |
| Boiling point | 508.1±43.0 °C(Predicted) | | density | 1.087±0.06 g/cm3(Predicted) | | storage temp. | -20° | | solubility | Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml). | | form | solid | | pka | 12.68±0.46(Predicted) | | color | Off-white | | Stability: | Stable for 2 years from date of purchse as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months. |
| | CAY10683 (SantacruzaMate A) Usage And Synthesis |
| Description | Santacruzamate A (1477949-42-0) is a highly potent and selective inhibitor of HDAC2 isolated from the Panamanian marine cyanobacterium?cf. Symploca?(IC50=0.119 and 434 nM for HDAC2 and HDAC6 respectively).1?Induces apoptosis and cancer cell death only in combination with other HDAC1 inhibitors.2?Potential therapeutic agent for breast cancer.3?Attenuates Aβ fragment (Aβ25-35)-induced toxicity in PC12 cells by enhancing ER stress tolerance.4?Ameliorates Alzheimer’s disease-like pathology in mouse models.4 | | Uses | Santacruzamate A is a natural product isolated from Panamanian marine cyanobacterium Symploca sp; a histone deacetylases (HDACs) inhibitor; an attractive targeted therapy against breast cancer in women. | | Definition | ChEBI: Santacruzamate A is an organooxygen compound and an organonitrogen compound. It is functionally related to a gamma-amino acid. | | storage | Store at -20°C | | References | 1) Pavlik?et al.?(2013),?Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp.; J. Nat. Prod.,?76?2026
2) Zhou?et al.?(2018),?Pharmacological or transcriptional inhibition of both HDAC1 and 2 leads to cell cycle blockage and apoptosis via p21Waf1/Cip1 and p19INK4d upregulation in hepatocellular carcinoma; Cell Prolif.,?51(3)?e12447
3) Damaskos?et al.?(2017),?Histone Deacetylase Inhibitors: An Attractive Therapeutic Strategy Against Breast Cancer;?Anticancer Res.,?37?35
4) Chen?et al.?(2019),?Santacruzamate A Ameliorates AD-Like Pathology by Enhancing ER Stress Tolerance Through Regulating the Functions of KDELR and Mia40-ALR in vivo and in vitro;?Front. Cell. Neurosci.,?13?61 |
| | CAY10683 (SantacruzaMate A) Preparation Products And Raw materials |
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