KP372-1

KP372-1 Basic information
Product Name:KP372-1
Synonyms:KP372-1A;10H-indeno[2,1-e]tetrazolo[1,5-b][1,2,4]triazin-10-one;KP372-1;Akt Inhibitor (KP372-1);KP372-1 USP/EP/BP
CAS:329710-24-9
MF:C10H4N6O
MW:224.18
EINECS:
Product Categories:
Mol File:329710-24-9.mol
KP372-1 Structure
KP372-1 Chemical Properties
density 2.01±0.1 g/cm3(Predicted)
pka-3.26±0.20(Predicted)
Safety Information
MSDS Information
KP372-1 Usage And Synthesis
UsesKP372-1 is a specific Akt inhibitor that demonstrates at least 10-fold selectivity against a panel of additional kinase targets, including CDK1, ERK1, GSK3β, LCK, MEK1, PKA, PKC, and S6K. By blocking Akt signaling, KP372-1 has been shown to inhibit proliferation and to induce apoptosis of thyroid cancer cells.
KP372-1 Preparation Products And Raw materials
1 VIAL PROTEASE-INHIBITOR-MIX FY 1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol

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