ChemicalBook Product Catalog Pharmaceutical intermediates Heterocyclic compound Pyrimidines Fluoropyrimidine 2,4-DIFLUOROPYRIMIDINE

2,4-DIFLUOROPYRIMIDINE

2,4-DIFLUOROPYRIMIDINE Basic information
Synthesis
Product Name:2,4-DIFLUOROPYRIMIDINE
Synonyms:2,4-DIFLUOROPYRIMIDINE;NSC 331813;EOS-61621;Pyrimidine, 2,4-difluoro- (6CI,8CI,9CI);2,4-Difluoropyrimidine 98%;2,4-Difluoropyrimidine98%;Pyrimidine, 2,4-difluoro-;2,4-DIFLUOROPYRIMIDINE ISO 9001：2015 REACH
CAS:2802-61-1
MF:C4H2F2N2
MW:116.07
EINECS:631-074-8
Product Categories:PYRIMIDINE;Halides;Pyrazines, Pyrimidines & Pyridazines;Heterocyclic Compounds;Pyrazines, Pyrimidines & Pyridazines;Building Blocks;Heterocyclic Building Blocks;Pyrimidines
Mol File:2802-61-1.mol
2,4-DIFLUOROPYRIMIDINE Structure
2,4-DIFLUOROPYRIMIDINE Chemical Properties
Boiling point 118-120 °C
density 1.359 g/mL at 25 °C
refractive index n20/D 1.432
Fp 106 °F
pka-2.52±0.20(Predicted)
form liquid
color Clear, colourless
CAS DataBase Reference2802-61-1(CAS DataBase Reference)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 10-22-37/38-41
Safety Statements 26-39
RIDADR UN 1993 3/PG 3
WGK Germany 3
Hazard Note Irritant
HazardClass 3
PackingGroup III
HS Code 29335990
MSDS Information
ProviderLanguage
SigmaAldrich English
2,4-DIFLUOROPYRIMIDINE Usage And Synthesis
SynthesisCrown ethers are able to enhance the performance of KF in two ways. Firstly, they complex the potassium cation making a better fluoride source and secondly they increase the solubility of KF in the solvent. KF with a catalytic amount of dicyclohexano-18-crown-6 in tetraglyme converted 2,4-dichloropyrimidine into 2,4-difluoropyrimidine.
Uses2,4-Difluoropyrimidine can be used as a starting material to synthesize:
  • 3-Pyrimidin-4-yl-oxazolidin-2-one derivatives as mutant isocitrate dehydrogenase (IDH1) inhibitors.
  • N,N′-(1,4-phenylenebis(methylene))bis(2-fluoropyrimidin-4-amine) as chemokine receptor type 4 antagonists.

Synthesis Reference(s)Journal of Heterocyclic Chemistry, 22, p. 149, 1985 DOI: 10.1002/jhet.5570220137
2,4-DIFLUOROPYRIMIDINE Preparation Products And Raw materials
Raw materials2,4-Dichloropyrimidine
Preparation ProductsPyrimidine, 4-chloro-2-fluoro- (9CI)
4-Pyrimidinamine,2,6-difluoro-N-methyl- 5-CHLORO-2,4-DIFLUORO-6-METHYL-PYRIMIDINE 2,4,6-TRIFLUORO-5-METHYLPYRIMIDINE 2,4,6-TRIFLUOROPYRIMIDINE 3,5-Difluoropyridine-2,6-diamine 2,5-Difluoropyrimidine 5-Chloro-2,4,6-trifluoropyrimidine 5-BROMO-2,4-DIFLUOROPYRIMIDINE 3,5-Difluoropyridine 2,5-Difluoropyridine 4-AMINO-2,6-DIFLUOROPYRIMIDINE 2-MORPHOLINO-4,6-DIFLUOROPYRIMIDINE,98% 5-BROMO-4,6-DIFLUOROPYRIMIDINE 2-ETHOXY-4,6-DIFLUOROPYRIMIDINE disodium 7-[(5-chloro-2,6-difluoropyrimidin-4-yl)amino]-4-hydroxy-3-[(4-methoxy-2-sulphonatophenyl)azo]naphthalene-2-sulphonate 2,6-DIFLUORO-5-METHYLPYRIMIDIN-4-YLAMINE 2,4-DIFLUOROPYRIMIDINE 2,4,5,6-Tetrafluoropyrimidine
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