7-DeMethyl Ivabradine

7-DeMethyl Ivabradine Basic information
Product Name:7-DeMethyl Ivabradine
Synonyms:3-[3-[[[(7S)-3,4-DiMethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]Methyl]MethylaMino]propyl]-1,3,4,5-tetrahydro-7-hydroxy-8-Methoxy-H-3-benzazepin-2-one;7-DeMethyl Ivabradine;7-O-Desmethyl Ivabradine;Ivabradine Impurity j;3-[3-[[[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7-hydroxy-8-methoxy-2H-3-benzazepin-2-one;Ivabradine Impurity D (7-Demethyl Ivabradine);Ivabradine 7-O-Desmethyl Impurity;3-[3-[[(7S)-3,4-dimethoxy-7-bicyclo[4.2.0]octa-1,3,5-trienyl]methyl-methylamino]propyl]-8-hydroxy-7-methoxy-2,5-dihydro-1H-3-benzazepin-4-one
CAS:304462-60-0
MF:C26H34N2O5
MW:454.56
EINECS:
Product Categories:Amines, Chiral Reagents, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals;Amines;Chiral Reagents;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
Mol File:304462-60-0.mol
7-DeMethyl Ivabradine Structure
7-DeMethyl Ivabradine Chemical Properties
Melting point >50°C (dec.)
Boiling point 643.9±55.0 °C(Predicted)
density 1.186±0.06 g/cm3(Predicted)
storage temp. Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility Methanol (Slightly)
pka9.95±0.20(Predicted)
form Solid
color Off-White to Pale Beige
Safety Information
MSDS Information
7-DeMethyl Ivabradine Usage And Synthesis
UsesIvabradine (I940500) metabolite.
Uses7-Demethyl Ivabradine is an impurity of Ivabradine (I940500), which is a selective bradycardic agent with direct effect on the pacemaker If current of the sinoatrial node. Antianginal.
7-DeMethyl Ivabradine Preparation Products And Raw materials
(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride 4,5-Dimethoxy-1-cyanobenzocyclobutane (Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one Ivabradine Impurity 70 3,3'-(propane-1,3-diyl)bis(7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one) 3-(3-Chloropropyl)-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-3-benzazepin-2-one N-(2,2-dimethoxy-ethyl)-3,4-dimethoxyphenylacetamide Hydroxy Ivabradine (3,4-Dimethoxyphenyl)acetic acid C-(3,4-DIMETHOXY-BICYCLO[4.2.0]OCTA-1(6),2,4-TRIEN-7-YL)-METHYLAMINE 3,3'-(propane-1,3-diyl)bis(7,8-dimethoxy-1,3-dihydro-2H-benzo[d]azepin-2-one) Ivabradine Impurity 1 Hydrochloride 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one Nalfurafine 3-[3-[[[(7S)-3,4-DiMethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]Methyl]MethylaMino]propyl]-1,3-dihydro-7,8-diMethoxy-H-3-benzazepin-2-one Ivabradine Impurity n 3-(3-hydroxypropyl)-7,8-dimethoxy-1,3-dihydro-2H-benzo[d]azepin-2-one Ivabradine IMpurity D

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