Δ2-Cefuroxime Axetil

Δ2-Cefuroxime Axetil Basic information
Product Name:Δ2-Cefuroxime Axetil
Synonyms:Δ2-Cefuroxime Axetil;(6R,7R)-3-[[(AMinocarbonyl)oxy]Methyl]-7-[[(2Z)-2-(2-furanyl)-2-(MethoxyiMino)acetyl]aMino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylic Acid 1-(Acetyloxy)ethyl Ester;[6R-[6α, 7β(Z)]]-3-[[(Aminocarbonyl)oxy]methyl]-7-[[2-furanyl(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylic acid 1-(acetyloxy)ethyl ester;Cefuroxim axetil impurity A;Cefuroxim Impurity 34;5-Thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylic acid, 3-[[(aminocarbonyl)oxy]methyl]-7-[[(2Z)-2-(2-furanyl)-2-(methoxyimino)acetyl]amino]-8-oxo-, 1-(acetyloxy)ethyl ester, (6R,7R)-;Δ2-Cefuroxime Axetil (Cefuroxime Axetil Delta-3 Isomer);1-acetyloxyethyl (6R,7R)-3-(carbamoyloxymethyl)-7-[[(2Z)-2-(furan-2-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylate
CAS:123458-61-7
MF:C20H22N4O10S
MW:510.47
EINECS:
Product Categories:Chiral Reagents, Drug Analogues, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds;Chiral Reagents;Drug Analogues;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
Mol File:123458-61-7.mol
Δ2-Cefuroxime Axetil Structure
Δ2-Cefuroxime Axetil Chemical Properties
Melting point 64-71°C
density 1.61±0.1 g/cm3(Predicted)
storage temp. Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility DMSO (Slightly), Methanol (Slightly)
form neat
pka8.33±0.60(Predicted)
color White to Pale Yellow
Stability:Hygroscopic
Safety Information
MSDS Information
Δ2-Cefuroxime Axetil Usage And Synthesis
UsesIt is an oral prodrug of Cefuroxime (C248060), an injectable second generation cephalosporin with an excellent antibacterial activity. This ester is applied in therapy as a mixture of the R and S diastereoisomers.
UsesΔ2-Cefuroxime Axetil (Cefuroxime Axetil EP Impurity A) is an oral prodrug of Cefuroxime (C248060), an injectable second generation cephalosporin with an excellent antibacterial activity. This ester is applied in therapy as a mixture of the R and S diastereoisomers.
Δ2-Cefuroxime Axetil Preparation Products And Raw materials
Cefuroxime 1-acetoxyethyl ester Cefuroxime Sodium EP Impurity G (αZ)-α-(MethoxyiMino)-N-[(5aR,6R)-1,4,5a,6-tetrahydro-1,7-dioxo-3H,7H-azeto[2,1-b]furo[3,4-d][1,3]thiazin-6-yl]-2-furanacetaMide

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