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| | Ginsenoside Rb1 Basic information |
| | Ginsenoside Rb1 Chemical Properties |
| Melting point | 197.5°C | | Boiling point | 766.35°C (rough estimate) | | density | 1.0971 (rough estimate) | | refractive index | 1.6500 (estimate) | | storage temp. | 2-8°C | | solubility | methanol: soluble9.80 - 10.20 mg/mL, clear, colorless to faintly yellow | | pka | 12.85±0.70(Predicted) | | form | neat | | color | Off-White to Pale Beige | | Stability: | Hygroscopic | | LogP | 2.900 (est) | | CAS DataBase Reference | 41753-43-9(CAS DataBase Reference) |
| | Ginsenoside Rb1 Usage And Synthesis |
| Uses | A major bioactive component of panax ginseng that promotes neurotransmitter release by modulating phosphorylation of synapsins through a cAMP-dependent protein kinase pathway. It has been reported to display immunostimulatory and anticancer effects. | | Uses | Reference standard in the analysis of herbal medicinal products. | | Definition | ChEBI: Ginsenoside Rb1 is a ginsenoside found in Panax ginseng and Panax japonicus var. major that is ginsenoside Rd in which the beta-D-glucopyranoside group at position 20 is replaced by a beta-D-glucopyranosyl-beta-D-glucopyranoside group. It has a role as a neuroprotective agent, an anti-obesity agent, an anti-inflammatory drug, an apoptosis inhibitor, a radical scavenger and a plant metabolite. It is a ginsenoside, a glycoside and a tetracyclic triterpenoid. It is functionally related to a ginsenoside Rd. | | General Description | Ginsenoside Rb1 (Gypenoside Ⅲ) is a protopanaxadiol that has diverse in vitro and in vivo effects, including neuroprotective, anti-inflammatory, and anti-obesity actions. Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na+, K+-ATPase activity with IC50 of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65. Ginsenoside Rb1 reduces the expressions of TLR3, TLR4 and TRAF-6, and down-regulates the levels of TNF-α, IFN-β and iNOS. | | Biochem/physiol Actions | Triterpene saponin found in ginseng. | | Safety Profile | Poison by intravenous route. Moderately toxic by intraperitoneal route. Mutation data reported. Whenheated to decomposition it emits acrid smoke and irritating fumes. | | target | p38MAPK | JNK | GLUT | Akt | IFN-γ | IL Receptor | GSK-3 | HO-1 | PKA | Estrogen receptor | Progestogen receptor |
| | Ginsenoside Rb1 Preparation Products And Raw materials |
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