Ramiprilat

Ramiprilat Basic information
Product Name:Ramiprilat
Synonyms:RAMIPRILAT;RAMIPRILAT HYDRATE;Ramiprilat, ammonium salt;Ramipril EP Impurity E (Ramiprilat);Ramipril Impurity V:Ramiprilat;Ramipril EP Imp E (acid);(2S,3aS,6aS)-1-[(2S)-2-[[(1S)-1-Carboxy-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[b]pyrrole-2-carboxylic Acid;HOE 498 Diacid
CAS:87269-97-4
MF:C21H28N2O5
MW:388.46
EINECS:258-696-9
Product Categories:Various Metabolites and Impurities;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
Mol File:87269-97-4.mol
Ramiprilat Structure
Ramiprilat Chemical Properties
Melting point 139-141°C
Boiling point 632.2±55.0 °C(Predicted)
density 1.273±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,2-8°C
solubility DMSO (Slightly), Methanol (Slightly)
pka2.20±0.10(Predicted)
form Solid
color White to Pale Yellow
Stability:Hygroscopic
Safety Information
Hazard Codes Xi
Risk Statements 36/38
Safety Statements 26-37/39
MSDS Information
Ramiprilat Usage And Synthesis
DescriptionRamiprilat is the active metabolite of ramipril and functions as an angiotensin-converting enzyme inhibitor (pKi = 9.08 in human heart) to suppress the conversion of angiotensin I to angiotensin II and the degradation of bradykinin, thereby preventing vasoconstriction. Furthermore, ramiprilat is reported to interfere with the targeting of B2 kinin receptors to endothelial cell membranes further preventing bradykinin signaling. In addition to its cardioprotective effects in both animal models and clinical studies, ramiprilat has been reported to inhibit matrix metalloproteinase-3 and -9 activity in isolated Crohn’s disease fistulas.
Chemical PropertiesWhite to Off-White Solid
UsesA metabolite of Ramipril (R111000).
UsesRamiprilat (Ramipril EP Impurity E) is a metabolite of Ramipril (R111000), and acts as an ACE inhibitor (1). Reduces the need for dialysis among patients previously on angiotensin-converting-enzyme inhibitors (2). Ramipril is used in stroke prevention. (3)
DefinitionChEBI: A dipeptide that is the active metabolite of ramipril. An angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure and congestive heart failure.
in vitropretreatment with ramiprilat could significantly attenuate the recovery of b2 kinin receptors in while increasing that from membranes lacking caveolin, and such effect was not because of the inhibition of bradykinin degradation. ramiprilat could also decrease [3h]bradykinin binding to cr membranes. in addition, ramiprilat treatment led to reactivation of the b2 receptor in bradykinin-stimulated cells [1].
in vivoin previous animal study, when compared with the control rats, diabetic rats showed decreased creatinine clearance rate, increased urinary protein excretion and blood pressure, as well as development of tubulointerstitial fibrosis, glomerulosclerosis, and inflammatory cell infiltration. furthermore, the blocking angiotensin ii with ramipril (the prodrug of ramiprilat) was able to significantly improve all of these parameters [2].
references[1] t. benzing, i. fleming, a. blaukat, et al. angiotensin-converting enzyme inhibitor ramiprilat interferes with the sequestration of the b2 kinin receptor within the plasma membrane of native endothelial cells. circulation 99(15), 2034-2040 (1999).
[2] li c, yang cw, park cw, ahn hj, kim wy, yoon kh, suh sh, lim sw, cha jh, kim ys, kim j, chang ys, bang bk. long-term treatment with ramipril attenuates renal osteopontin expression in diabetic rats. kidney int. 2003 feb;63(2):454-63.
[3] warner gt, perry cm. ramipril: a review of its use in the prevention of cardiovascular outcomes. drugs. 2002;62(9):1381-405.
Ramiprilat Preparation Products And Raw materials
Carboxy styrene-butadiene latex Ramipril (1R) RAMIPRILAT-D5 N-Methyl-2-pyrrolidone RAMIPRILAT-D3 N-Vinyl-2-pyrrolidone RAMIPRIL ACYL-B-D-GLUCURONIDE RAMIPRILAT ACYL-B-D-GLUCURONIDE Polyvinylpyrrolidone RAMIPRIL-D5 ACYL-B-D-GLUCURONIDE RAMIPRILAT-D5 ACYL-B-D-GLUCURONIDE Ramiprilat Diketopiperazine-d5 Ramiprilat RAMIPRILAT-D5 Ramiprilat Acyl Glucuronide 2-[N-[(S)-1-ETHOXYCARBONYL-3-PHENYLPROPYL]-L-ALANYL]-(1S,3S,5S)-2-AZABICYCLO[3.3.0]OCTANE-3-CARBOXYLIC ACID, BENZYL ESTER RAMIPRIL-D3 Pyrrolidine

Email:[email protected] [email protected]
Copyright © 2025 Mywellwork.com All rights reserved.