ChemicalBook Product Catalog API Antineoplastic agents Antimetabolites, Antineoplastic 4-Hydroxy-5-fluorpyrimidine

4-Hydroxy-5-fluorpyrimidine

4-Hydroxy-5-fluorpyrimidine Basic information
Product Name:4-Hydroxy-5-fluorpyrimidine
Synonyms:4-hydroxy-5-fluorpyrimidin;5-fluoro-4(1h)-pyrimidinon;fluoxidine;fluoxydine;5-Fluor-4-pyrimidinol;5-FLUORO-4-HYDROXYPYRIMIDINE;5-Fluoro-4(1H)-pyrimidinone;5-fluoro-3h-pyrimidin-4-one
CAS:671-35-2
MF:C4H3FN2O
MW:114.08
EINECS:
Product Categories:PYRIMIDINE;APIs & Intermediate;Fluorine series
Mol File:671-35-2.mol
4-Hydroxy-5-fluorpyrimidine Structure
4-Hydroxy-5-fluorpyrimidine Chemical Properties
Melting point 204-205 °C(Solv: water (7732-18-5))
density 1.3658 (estimate)
storage temp. Inert atmosphere,Room Temperature
pka7.13±0.40(Predicted)
CAS DataBase Reference671-35-2(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
HS Code 29335990
MSDS Information
4-Hydroxy-5-fluorpyrimidine Usage And Synthesis
Chemical PropertiesOff-white solid
Uses5-Fluoro-4-hydroxypyrimidine is a precursor in the synthesis of the antifungal Voriconazole (V760000). Also used as a reagent in the synthesis of 4-methyl-1,2,3-thiadiazole-5-carboxylates as antiviral agents, activators, and fungicides for treatment and prevention of plant diseases such as tobacco mosaic virus.
4-Hydroxy-5-fluorpyrimidine Preparation Products And Raw materials
Raw materialsMethanol-->Formamidine acetate-->Ethyl fluoroacetate
(2Z)-2-{4-[(2-CHLORO-5-FLUOROPYRIMIDIN-4-YL)OXY]BENZYLIDENE}[1,3]THIAZOLO[3,2-A]BENZIMIDAZOL-3(2H)-ONE 2,4-DIMETHOXY-5-FLUOROPYRIMIDINE O,O'-BIS(TRIMETHYLSILYL)-5-FLUOROURACIL CHEMBRDG-BB 6873131 (2Z)-3-{4-[(2-CHLORO-5-FLUOROPYRIMIDIN-4-YL)OXY]PHENYL}-2-CYANO-N-(2,4-DIMETHYLPHENYL)ACRYLAMIDE (2Z)-3-{4-[(2-CHLORO-5-FLUOROPYRIMIDIN-4-YL)OXY]PHENYL}-2-(MORPHOLIN-4-YLCARBONYL)ACRYLONITRILE 5-FLUORO-2'-O-METHYLURIDINE L-2-MERCAPTO-4-HYDROXY-5-FLUOROPYRIMIDINE 2-Methoxy-5-fluorouracil 3-[(2-CHLORO-5-FLUORO-4-PYRIMIDINYL)OXY]-4-METHOXYBENZALDEHYDE 5-fluoropyrimidine-2,4-diol 2-Ethoxy-5-fluoro-1H-pyrimidin-4-one {4-[(2-CHLORO-5-FLUOROPYRIMIDIN-4-YL)OXY]-3-METHOXYBENZYLIDENE}MALONONITRILE 4(1H)-Pyrimidinone, 5-fluoro-2-((2-methylphenyl)methyl)- 4-[(2-CHLORO-5-FLUORO-4-PYRIMIDINYL)OXY]BENZALDEHYDE 4-Ethyl-5-fluoro-6-hydroxypyrimidine 4-Pyrimidinol, 5-fluoro-2-methyl- (7CI,8CI) 5-FLUORO-2-PHENYLPYRIMIDIN-4-OL
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