Dihydrostreptomycin sulfate

Dihydrostreptomycin sulfate Basic information

Product Name:	Dihydrostreptomycin sulfate
Synonyms:	D-Streptamine, O-2-deoxy-2-(methylamino)-.alpha.-L-glucopyranosyl-(1?2)-O-5-deoxy-3-C-(hydroxymethyl)-.alpha.-L-lyxofuranosyl-(1?4)-N,N-bis(aminoiminomethyl)-, sulfate (2:3) (salt);dihydrostreptomycin solution;DIHYDROSTREPTOMYCINSULPHATE(INJ.);DIHYDROSTREPTOMYCINSULPHATE(ORAL);dihydrostreptomycin3/2sulfate;dihydro-streptomycisulfate(2:3)(salt);d-streptamine,o-2-deoxy-2-(methylamino)-alpha-l-glucopyranosyl-(1.fwdarw.2)-o;n’-bis(aminoiminomethyl)--3-c-(hydroxymethyl)-alpha-l-lyxofuranosyl-(1-4)-
CAS:	5490-27-7
MF:	C21H43N7O16S
MW:	681.67
EINECS:	226-823-7
Product Categories:	Agro-Products;Amines;Carbohydrates & Derivatives;Intermediates & Fine Chemicals;PHARMACEUTICALS;A - KAntibiotics;AminoglycosidesAntibiotics;Antibiotics A-FAntibiotics;Antibiotics by Application;AntimycobacterialAntibiotics;Chemical Structure Class;Genetic Marker SelectionAntibiotics;Interferes with Protein SynthesisMore...Close...;Mechanism of Action;Antibacterial;Antibiotics A to;Spectrum of Activity
Mol File:	5490-27-7.mol

Dihydrostreptomycin sulfate Chemical Properties

alpha	D25 -88.5° (1% soln)
storage temp.	Inert atmosphere,2-8°C
solubility	H₂O: 50 mg/mL, clear, faintly yellow
form	crystalline
color	white to light yellow
Water Solubility	Soluble in water
Merck	13,3201
BRN	3894221
Stability:	Hygroscopic
EPA Substance Registry System	D-Streptamine, O-2-deoxy-2-(methylamino)-.alpha.-L-glucopyranosyl-(1.fwdarw.2)-O-5-deoxy-3-C-(hydroxymethyl)-.alpha.-L-lyxofuranosyl-(1.fwdarw.4)-N,N'-bis(aminoiminomethyl)-, sulfate (2:3) (salt) (5490-27-7)

Safety Information

MSDS Information

Dihydrostreptomycin sulfate Usage And Synthesis

Chemical Properties	White Solid
Originator	Dihydrostrepto,MSD ,US,1948
Uses	Dihydrostreptomycin sesquisulfate is used in veterinary medicine to treat bovine infection and also as an effective antibiotic to control pests found in crops.. Other studies have also used it as an electrode for a cochlear amplifier in the hair-cell bundle of lizards.
Uses	antibacterial, tuberculostatic
Uses	As a derivative of Streptomycin (S687500) with antimicrobial activity, Dihydrostreptomycin sulfate is used in veterinary medicine to treat bovine infection and also as an effective antibiotic to control pests found in crops.
Manufacturing Process	Dihydrostreptomycin sulfate may be prepared from streptomycin sulfate by catalytic hydrogenation (Merck, Pfizer, Cyanamid), electrolytic reduction (Schenley, Olin Mathieson), or by sodium borohydride reduction (Bristol), or by isolation from a fermentation process (Takeda).
Therapeutic Function	Antibiotic
Purification Methods	It crystallises from H2O, MeOH, n-BuOH or methyl ethyl ketone. The crystals are not hygroscopic like the amorphous powder; however, both forms are soluble in H2O but the amorphous solid is about 10 times more soluble than the crystals. The free base also crystallises from H2O/Me2CO and has [] D -92o (aqueous solution pH 7.0). [Solomons & Regina Science 109 515 1949, Wolf et al. Science 109 515 1949, McGilveray & Rinehart J Am Chem Soc 87 4003 1956]. [Beilstein 18 III/IV 7538.]

Dihydrostreptomycin sulfate Preparation Products And Raw materials

Raw materials

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