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| | 2-CHLORO-4-(METHYLSULFONYL)ANILINE Basic information |
| Product Name: | 2-CHLORO-4-(METHYLSULFONYL)ANILINE | | Synonyms: | 2-chloro-4-(methylsulfonyl)-anilin;2-chloro-4-(methylsulfonyl)-benzenamin;4-amino-3-chlorofenylomethylosulfon;4-amino-3-chlorophenylmethylsulfone;4-amino-3-chlorophenylmethylsulphone;TIMTEC-BB SBB003494;2-CHLORO-4-(METHYLSULFONYL)ANILINE;LABOTEST-BB LT00441295 | | CAS: | 13244-35-4 | | MF: | C7H8ClNO2S | | MW: | 205.66 | | EINECS: | 236-225-8 | | Product Categories: | | | Mol File: | 13244-35-4.mol |  |
| | 2-CHLORO-4-(METHYLSULFONYL)ANILINE Chemical Properties |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 37/39-26 | | Hazard Note | Irritant | | HS Code | 29309099 |
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ACROS
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| | 2-CHLORO-4-(METHYLSULFONYL)ANILINE Usage And Synthesis |
| Chemical Properties | pale purple to grey-brown crystalline powder | | Uses | 2-Chloro-4-methylsulphonylaniline can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and pharmaceutical and chemical production processes. | | Synthesis | 
A mixture of 2-chloro-4-methylsulfonyl-1- nitro-benzene (4.5 g, 19.10 mmol, 1 eq.) in EtOH (40 mL) and a saturated NH4Cl solution (10 mL) was heated to 90 °C, and then Fe (3.20 g, 57.29 mmol, 3 eq.) was added in one portion. The reaction mixture was stirred at 90 °C for 1 h, after which time TLC analysis (PE:EtOAc = 1:1, Rf(starting material) = 0.7, Rf(product) = 0.31) indicated that the reaction was complete. The reaction was diluted with water (50 mL) and extracted with EtOAc (100 mL x 3). The combined organic layers were washed with water (50 mL x 3) and brine (50 mL x 2), dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The residue was purified by column chromatography (SiO2, PE:EtOAc = 4:1 to 2:1) to provide 2-chloro-4-methylsulfonyl-aniline (3.7 g, 17.99 mmol, 94.21% yield) as an off-white solid. |
| | 2-CHLORO-4-(METHYLSULFONYL)ANILINE Preparation Products And Raw materials |
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