2,5-Dihydroxybenzaldehyde

2,5-Dihydroxybenzaldehyde Basic information
Product Name:2,5-Dihydroxybenzaldehyde
Synonyms:2,5-Dihydroxybenzaldehyde SynonyMs Gentisaldehyde;2,5-Dihydroxybenzaldehyde Vetec(TM) reagent grade, 98%;2,5-Dihydroxybenzaldehyde, 98% or higher by HPLC;GENTISIC ALDEHYDE;GENTISINALDEHYDE;5-HYDROXYSALICYLALDEHYDE;2,5-DIHYDROXYBENZALDEHYDE;Benzaldehyde, 2,5-dihydroxy-
CAS:1194-98-5
MF:C7H6O3
MW:138.12
EINECS:214-789-6
Product Categories:Aromatic Aldehydes & Derivatives (substituted);Aromatics;Aldehydes;Phenyls & Phenyl-Het;Benzaldehyde;Phenyls & Phenyl-Het;1;1194-98-5
Mol File:1194-98-5.mol
2,5-Dihydroxybenzaldehyde Structure
2,5-Dihydroxybenzaldehyde Chemical Properties
Melting point 97-99 °C (lit.)
Boiling point 213.5°C (rough estimate)
density 1.2667 (rough estimate)
refractive index 1.4797 (estimate)
storage temp. Store below +30°C.
solubility 13.8g/l soluble
form Crystalline Powder
pka8.89±0.18(Predicted)
color Yellow to khaki-green
Water Solubility soluble
Sensitive Air Sensitive
BRN 1363961
InChIKeyCLFRCXCBWIQVRN-UHFFFAOYSA-N
LogP0.540
CAS DataBase Reference1194-98-5(CAS DataBase Reference)
NIST Chemistry Reference2,5-Dihydroxybenzaldehyde(1194-98-5)
EPA Substance Registry SystemBenzaldehyde, 2,5-dihydroxy- (1194-98-5)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38-43
Safety Statements 26-36/37/39-37/39-26,37/39-36
WGK Germany 3
Hazard Note Irritant
TSCA Yes
HS Code 29124990
MSDS Information
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2,5-Dihydroxybenzaldehyde Usage And Synthesis
Description2,5-Dihydroxybenzaldehyde is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activity.
Chemical Propertiesyellow to khaki-green crystalline powder
Uses2,5-Dihydroxybenzaldehyde (cas# 1194-98-5) is a compound useful in organic synthesis.
DefinitionChEBI: 2,5-dihydroxybenzaldehyde is a dihydroxybenzaldehyde carrying hydroxy groups at positions 2 and 5. It has a role as a Penicillium metabolite, a mouse metabolite and a human metabolite.
PreparationAdd 80 mmol of dry paraformaldehyde to a mixture of 12 mmol of the phenol derivative and 2.5 mmol of MgO nanocrystalline (0.1 g). Expose the resulting mixture under microwave irradiation with a power of 650 W. Monitor the progress of the reaction by thin layer chromatography (TLC) developed by n-hexane : ethyl acetate (8 : 2). Add 100 mL of sulfuric acid (15% w/w) to the reaction mixture and heated at 50 °C for 15 min. Cool the reaction mixture to room temperature. Extract the product by dichloromethane (2 x 50 mL). Dry the organic layer over anhydrous magnesium sulphate. Evaporate the solution resulting from filtration to obtain the crude product. Purify the other product by column chromatography using n-hexane : ethyl acetate (95 : 5 to 70 : 30).
synthesis of 2,5-Dihydroxybenzaldehyde
2,5-Dihydroxybenzaldehyde Preparation Products And Raw materials
Preparation Products2,5-DIETHOXYBENZALDEHYDE-->1,4-Cyclohexadiene-1-carboxaldehyde, 3,6-dioxo--->1',3',3'-TRIMETHYL-6-HYDROXYSPIRO(2H-1-BENZOPYRAN-2,2'-INDOLINE)-->Ethyl 6-hydroxy-2-oxo-2H-chromene-3-carboxylate-->7-HYDROXYCOUMARIN-3-CARBOXYLICACID
6,7-DICHLORO-1,4-DIHYDROXYANTHRAQUINONE, 97 2,5-DIMETHOXYBENZOYL CHLORIDE 2,4-dihydroxybenzaldehyde [2-(3,5-dibromo-2-hydroxyphenyl)-6-methyl-4-pyrimidinyl]hydrazone 5-Methoxysalicylic acid 2-BROMO-2',5'-DIMETHOXYACETOPHENONE 1,4-DIHYDROXY-2,3-DIMETHYLANTHRAQUINONE ACID GREEN 41 2,4-Dihydroxybenzaldehyde 2,4-dinitrophenyl hydrazone 1,2,5,8-TETRAHYDROXYANTHRAQUINONE 2',5'-DIHYDROXYPROPIOPHENONE 2,4-Dihydroxy-3-methylbenzaldehyde DIHYDROXY BENZALDEHYDE 2-HYDROXY-5-METHOXYBENZOIC ACID SODIUM 2,3-Dihydroxybenzaldehyde 2-benzothiazolyl hydrazone 2,5-Dimethoxybenzaldehyde 2,3-DIHYDRO-9,10-DIHYDROXY-1,4-ANTHRACENEDIONE 5,8-Dihydroxy-1,4-naphthoquinone 6,7-DIMETHOXY-2,2-DIMETHYL-4-CHLOROMANONE

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