2-Thiopheneacetic acid

2-Thiopheneacetic acid Basic information

Product Name:	2-Thiopheneacetic acid
Synonyms:	Thiophene-2-acetic acid, 98+%;2-THIOPHENE-2-ACETIC ACID;2-(Thien-2-yl)acetic acid 97%;2-THIOPHENEACETIC ACID;2-THIENYLACETIC ACID;2-THENYLACETIC ACID;2-(2-Thienyl)acetic acid;AKOS BBS-00003728
CAS:	1918-77-0
MF:	C6H6O2S
MW:	142.18
EINECS:	217-639-8
Product Categories:	Cephaloridine;Heterocycles;Thiophene&Benzothiophene;Organic acids;Thiophens;Drug Intermediates;thiophenes;bc0001
Mol File:	1918-77-0.mol

2-Thiopheneacetic acid Chemical Properties

Melting point	63-64 °C (lit.)
Boiling point	160 °C/22 mmHg (lit.)
density	1.365 (estimate)
refractive index	1.5300 (estimate)
Fp	160°C/22mm
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	Chloroform (Sparingly), Methanol (Slightly)
pka	4.23±0.10(Predicted)
form	Crystalline Powder
color	Slightly brown to brown
Water Solubility	Soluble in water, ethanol, ether and carbon tetrachloride.
BRN	114551
CAS DataBase Reference	1918-77-0(CAS DataBase Reference)
NIST Chemistry Reference	2-Thiopheneacetic acid(1918-77-0)
EPA Substance Registry System	2-Thiopheneacetic acid (1918-77-0)

Safety Information

Hazard Codes	C,Xi
Risk Statements	34-37-36/37/38
Safety Statements	26-36/37/39-45-24/25-27
RIDADR	UN 3261 8/PG 2
WGK Germany	3
Hazard Note	Irritant
TSCA	T
HazardClass	8
PackingGroup	III
HS Code	29349990

MSDS Information

Provider	Language
Thiophene-2-acetic acid	English
SigmaAldrich	English
ACROS	English
ALFA	English

2-Thiopheneacetic acid Usage And Synthesis

Chemical Properties	white to light yellow crystal powder
Uses	2-Thiopheneacetic acid is used in the preparation of rosette-like nanoscale gold materials. Further, it is used as a pharmaceutical intermediate for cefaloridine and cefalotin sodium.
Definition	ChEBI: 2-thienylacetic acid is a thiophene compound having a carboxymethyl group at the 2-position. It has a role as an allergen. It is a member of thiophenes and a monocarboxylic acid. It is functionally related to an acetic acid. It is a conjugate acid of a thien-2-ylacetate.
Synthesis Reference(s)	Canadian Journal of Chemistry, 46, p. 1057, 1968 DOI: 10.1139/v68-179 Journal of the American Chemical Society, 72, p. 4326, 1950
General Description	Adsorption of 2-thiopheneacetic acid on XAD-4, NDA-100 and ND-90 resin has been investigated. A new polymeric complex of Cu(II) and 2-thiopheneacetic acid has been synthesized and characterized by IR and Raman spectroscopy.
Purification Methods	Crystallise the acid from ligroin, hexane and/or distil it in a vacuum. The amide has m 148o (from H2O or pet ether). [Beilstein 18 H 293, 18 III/IV 4062, 18/6 V 207.]

2-Thiopheneacetic acid Preparation Products And Raw materials

Raw materials	Sulfur-->Thiophene-->2-Acetylthiophene-->THIOPHENE-2-ACETAMIDE-->2-Thiopheneacetic acid, 1-methylethyl ester-->2-Thiopheneacetic acid, α-methoxy--->2-Thiophenemethanol, α-(trichloromethyl)--->Thiophene, 2-(2-nitroethyl)--->2-(CHLOROACETYL)THIOPHENE-->2-Thiopheneacetaldehyde-->Ethyl 2-thiopheneacetate-->Methyl 2-thienylacetate-->2-Thiopheneacetonitrile
Preparation Products	2-Thiopheneacetyl chloride-->2-METHYL-THIOPHENE-3-CARBOXYLIC ACID-->Cephaloridine

α-Oxo-2-thiopheneacetic acid ethyl ester 3-METHYLTHIANAPHTHENE-2-ACETIC ACID Ethyl 2-(Chlorosulfonyl)acetate CHEMBRDG-BB 5190791 Ascoric Acid 2-[5-(4-FLUOROBENZOYL)-2-THIENYL]ACETIC ACID 2,3-DI-THIOPHEN-2-YL-ACRYLIC ACID 2-[5-(2,4-DICHLOROBENZOYL)-2-THIENYL]ACETIC ACID Methyl 2-thienylacetate ETHYL (5-BROMOTHIEN-2-YL)GLYOXYLATE (S)-α-Amino-2-thiopheneacetic acid 2-[5-(4-CHLOROBENZOYL)-2-THIENYL]ACETIC ACID 2-(5-BENZOYL-2-THIENYL)ACETIC ACID 2-[5-(2-CHLOROACETYL)-2-THIENYL]ACETIC ACID AMINO-THIOPHEN-2-YL-ACETIC ACID 2-[5-(4-METHOXYBENZOYL)-2-THIENYL]ACETIC ACID 2-Thiopheneacetic acid, 3-amino- α-Cyclohexyl-3-thiopheneacetic acid 1-methylethyl ester

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