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| | 1-[(2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione Basic information |
| Product Name: | 1-[(2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione | | Synonyms: | Ara-2'-F-2'-dT;2'-Deoxy-2'-fluoro-5-Methyl-beta-D-arabinouridine;1-(2-Deoxy-2-fluoro-b-D-arabinofuranosyl)-5-Methyluracil;D-FMAU;2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-methyl-;2'-Fluoro-5-methyl-1--D-arabinofuranosyluracil;1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione;1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-methyluracil | | CAS: | 69256-17-3 | | MF: | C10H13FN2O5 | | MW: | 260.22 | | EINECS: | 200-001-2 | | Product Categories: | | | Mol File: | 69256-17-3.mol | ![1-[(2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione Structure](CAS/GIF/69256-17-3.gif) |
| | 1-[(2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione Chemical Properties |
| density | 1.55±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 9.55±0.10(Predicted) |
| | 1-[(2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione Usage And Synthesis |
| Description | 2'-Fluoro-5-methyl-1-beta-D-arabinofuranosyluracil is the impurity of antiviral drug Clevudine (C574150), which is used for the treatment of Hepatitis B. | | Uses | 2''-Fluoro-5-methyl-1-β-D-arabinofuranosyluracil is the impurity of antiviral drug Clevudine (C574150), which is used for the treatment of Hepatitis B. |
| | 1-[(2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione Preparation Products And Raw materials |
| Raw materials | D-Arabinofuranose, 2-deoxy-2-fluoro-, 1,3-diacetate 5-benzoate-->D-Arabinofuranosyl bromide, 2-deoxy-2-fluoro-, 3-acetate 5-benzoate-->2-Deoxy-2-fluoro-alpha-D-arabinofuranosyl bromide 3,5-dibenzoate-->2-Deoxy-2-fluoro-1,3,5-tri-O-benzoyl-D-ribofuranose-->2'-fluoro-5-methylarabino-furanosylcytosine-->2,4(1H,3H)-Pyrimidinedione, 1-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-methyl--->5-METHYLCYTOSINE-->BIS(O-TRIMETHYLSILYL)THYMINE-->Thymine | | Preparation Products | 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-2-fluoro-α-D-arabinofuranosyl)-5-methyl- |
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