ChemicalBook Product Catalog Analytical Chemistry Standard Forensic and veterinary standards LY 267108

LY 267108

LY 267108 Basic information
Product Name:LY 267108
Synonyms:LY 267108;(2R,3R,6R,7S,8S,9R,10R)-7-[(2,6-Dideoxy-3-C-Methyl-3-O-Methyl-α-L-ribo-hexopyranosyl)oxy]-3-[(1R,2R)-1,2-dihydroxy-1-Methylbutyl]-2,6,8,10,12-pentaMethyl-9-[[3,4,6-trideoxy-3-(diMethylaMino)-β-D-xylo-hexopyranosyl]oxy]-4,13-dioxabicyclo[8.2.1]tridec-12-en-5-one;8,9-Anhydropseudo-erythroMycin A-6,9-heMiketal;(2R,3R,6R,7S,8S,9R,10R)-7-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy]-3-[(1R,2R)-1,2-dihydroxy-1-methylbutyl]-2,6,8,10,12-pentamethyl-9-[[3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl]oxy]-4,13-dioxabicyclo[8.2.1]tridec-12-en-5-one;NMIWBQUQCOMGHJ-XWVSLMRSSA-N;Erythromycin EP Impurity F/(2R,3R,6R,7S,8S,9R,10R)-3-((2R,3R)-2,3-dihydroxypentan-2-yl)-9-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-7-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-2,6;Erythromycin Impurit F:(pseudoerythromycin A enol ether);Erythromycin Impurity 15(Erythromycin EP Impurity F)
CAS:105882-69-7
MF:C37H65NO12
MW:715.91
EINECS:
Product Categories:Intermediates & Fine Chemicals;Metabolites & Impurities;Chromatography;Drugs&Metabolites;Forensic and Veterinary Standards;Pharmaceuticals;Neat CompoundsAnalytical Standards;Pharmacology Standards
Mol File:105882-69-7.mol
LY 267108 Structure
LY 267108 Chemical Properties
Melting point 127.0-130.0 °C
Boiling point 810.7±65.0 °C(Predicted)
density 1.20±0.1 g/cm3(Predicted)
storage temp. −20°C
solubility DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble
form neat
pka13.45±0.70(Predicted)
Safety Information
WGK Germany 3
MSDS Information
LY 267108 Usage And Synthesis
Chemical PropertiesWhite Solid
UsesPseudoerythromycin A enol ether is a degradation product of erythromycin formed by a complex internal rearrangement of erythromycin A on exposure to neutral to weakly alkaline conditions. The C6–OH forms an internal enol ether with the C9 ketone of erythromycin, while the C11-OH attacks the carbonyl of the lactone to reduce the macrocycle from a 14- to an 11-membered macrolide. Synthetically, pseudoerythromycin A enol ether is prepared by reacting erythromycin enol ether with carbonate. Pseudoerythromycin A enol ether is devoid of antibiotic activity but is an important analytical standard for erythromycin A stability studies.
UsesPseudo Erythromycin A Enol Ether (Erythromycin EP Impurity F) is an Erythromycin impurity.
UsesErythromycin impurity.
LY 267108 Preparation Products And Raw materials
Preparation ProductsERYTHROMYCIN OXIME
erythronolide B 16-Hydroxyerythromycin N-DEMETHYL ERYTHROMYCIN A Erythromycin ethylsuccinate Erythromycin EP Impurity L erythralosamine 3'-Demethyl-12-deoxyerythromycin Erythromycin, N-oxide LY 267108
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