Rimonabant hydrochloride

Rimonabant hydrochloride Basic information

Product Name:	Rimonabant hydrochloride
Synonyms:	RIMONABANT HYDROCHLORIDE;5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-n-1-piperidinyl-1h-pyrazole-3-carboxamide monohydrochloride;ACOMPLIA;ACOMPLIA (RIMONABANT;RIMONABANT HCL;Rimonabant(Acomplia);RimonabantConsultedStandard;Acomplia, SR141716
CAS:	158681-13-1
MF:	C22H21Cl3N4O.ClH
MW:	500.25
EINECS:	233-720-0
Product Categories:	SR141716;Aromatics;Cnbio;Inhibitors;Intermediates & Fine Chemicals;Heterocycles;API;Pharmaceuticals
Mol File:	158681-13-1.mol

Rimonabant hydrochloride Chemical Properties

Melting point	230-240°C
storage temp.	2-8°C
solubility	DMSO: soluble20mg/mL, clear
form	powder
color	white to beige
CAS DataBase Reference	158681-13-1(CAS DataBase Reference)

Safety Information

Hazard Codes	T,Xi
Risk Statements	25-36
Safety Statements	26-45
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	3

MSDS Information

Rimonabant hydrochloride Usage And Synthesis

Chemical Properties	White to Off-White Crystalline Solid
Uses	The first of a new class of selective (Cannabinoid-1 (CB-1) receptor antagonists
Uses	A brain cannabinoid receptor (CB1) antagonist. Antiobesity agent.
Uses	Rimonabant hydrochloride has been used as an antagonist of cannabinoid 1 (CB1) receptor: to study its effects on protein synthesis in C2C12 myotubes to analyze its effects on human astroglia in combination with methanandamide (mAEA) to study its effects on murine gastric vagal afferent mechanosensitivity
Hazard	A poison.
Biochem/physiol Actions	Rimonabant acts as a mycobacterial membrane protein large 3 (MMPL3) inhibitor. Rimonabant hydrochloride exhibits therapeutic activity against weight reduction and smoking cessation.
storage	Desiccate at RT

Rimonabant hydrochloride Preparation Products And Raw materials

Raw materials

Thionyl chloride-->Diethyl oxalate-->Potassium tert-butoxide-->Lithium diisopropylamide-->1-Aminopiperidine-->4'-Chloropropiophenone-->2,4-Dichlorophenylhydrazine hydrochloride

Chlorantraniliprole Methyl N,N-Dimethylformamide Parathion-methyl Topotecan hydrochloride Sibutramine hydrochloride 1-[(2-Chlorophenyl)-N-(methylimino)methyl]cyclopentanol hydrochloride Tramadol hydrochloride Rimonabant Chlorophenyl Dichloromethylphenylsilane Phenylphosphonic dichloride Kresoxim-methyl Benzamide 1-AdaMantanethylaMine Thiophanate-methyl Methyl salicylate Methyl bromide

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