ChemicalBook Product Catalog Organic Chemistry Organosulfur compounds 2-Methyl-2-thiopseudourea sulfate

2-Methyl-2-thiopseudourea sulfate

2-Methyl-2-thiopseudourea sulfate Basic information
Product Name:2-Methyl-2-thiopseudourea sulfate
Synonyms:s-methylthiouroniumsulfate(2:1);S-METHYL-ISO-THIOUREA;S-MethyliSothourea Sulfate;S-METHYLISOTHIOUREA HEMISULFATE NITRIC O XIDE SYNTHASE;S-Methylthioureasulfate=2-Methyl-2-thiopseudoureasulfate;2-Methyl-2-thiopseudourea sulphate;S-EIT hemihydrate;S-Methylisothiouroniumsulfate,98%
CAS:867-44-7
MF:C2H8N2O4S2
MW:188.23
EINECS:212-759-7
Product Categories:Cell Signaling and Neuroscience;Nitric Oxide and Cell Stress;Nitric Oxide Metabolism;Nitric Oxide Synthase Regulators;Bioactive Small Molecules;Building Blocks;pharmacetical;Nitric Oxide;Cell Biology;Chemical Synthesis;M;Organic Building Blocks;Sulfur Compounds;Thioureas
Mol File:867-44-7.mol
2-Methyl-2-thiopseudourea sulfate Structure
2-Methyl-2-thiopseudourea sulfate Chemical Properties
Melting point 240-241 °C (dec.)(lit.)
density 1.28
Fp 3℃
storage temp. Inert atmosphere,Room Temperature
solubility H2O: 0.1 g/mL, clear, colorless
pkapK1:9.83(＋1) (25°C)
form Crystals or Crystalline Powder
color White
PH5.5 (260g/l, H2O, 20℃)
Water Solubility 260 g/L (20 ºC)
Sensitive Hygroscopic
BRN 3917217
Stability:Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference867-44-7(CAS DataBase Reference)
EPA Substance Registry SystemCarbamimidothioic acid, methyl ester, sulfate (2:1) (867-44-7)
Safety Information
Hazard Codes Xn
Risk Statements 22
Safety Statements 22-24/25
WGK Germany 3
RTECS UM9200000
TSCA Yes
HS Code 29309070
MSDS Information
ProviderLanguage
2-Methyl-2-thiopseudourea sulfate English
2-Methyl-2-thiopseudourea sulfate Usage And Synthesis
DescriptionSMIT is a potent non-selective inhibitor of NOS isoforms in vitro but may lack good in vivo efficacy due to poor cellular penetration. The Ki values are 120, 200, and 160 nM using purified human iNOS, eNOS, and nNOS, respectively.
Chemical Propertieswhite crystalline powder
UsesIntermediate of 4-Hydroxydebrisoquine. S-Methyl-isothiouronium Hemisulfate is also a reagent used in the synthesis of strobilurin-pyrimidine derivatives for their anti-proliferative activity.
Biochem/physiol ActionsMore potent than NMMA as an inhibitor of inducible nitric oxide synthetase (iNOS).
2-Methyl-2-thiopseudourea sulfate Preparation Products And Raw materials
Preparation Products5-methoxy-2-(methylthio)pyrimidin-4-ol ,97%-->4-Chloro-2-(methylthio)pyrimidine-5-carbonitrile ,97%-->1-Methyl-3-nitro-1-nitrosoguanidine-->ETHYL 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLATE-->Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate-->Aminoguanidine bicarbonate-->1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER-->IMINOCTADINE TRIACETATE-->5-CHLORO-2-METHOXYPYRIMIDINE-4-CARBOXYLIC ACID-->1,1-DIMETHYLGUANIDINE SULFATE-->5-[2-(METHYLTHIO)PYRIMIDIN-4-YL]THIOPHENE-2-SULFONYL CHLORIDE-->5-Chloro-2-(methylsulfonyl)pyrimidine-->METHYL 5-BROMO-2-(METHYLSULFANYL)-4-PYRIMIDINECARBOXYLATE, 97-->4-Methoxy-6-methyl-2-(methylsulfonyl)pyrimidine ,97%-->5-CHLORO-2-(METHYLSULFONYL)PYRIMIDINE-4-CARBOXYLIC ACID-->5-Bromo-4-chloro-2-(methylthio)-7H-pyrrolo[2,3-D]pyrimidine ,97%-->5-BROMO-2-(METHYLSULFONYL)PYRIMIDINE-4-CARBOXYLIC ACID-->2-(METHYLTHIO)-4-(TRIFLUOROMETHYL)PYRIMIDINE-->4-(Trifluoromethyl)-2-(methylthio)pyrimidine-5-carboxylic acid ,97%-->4-Hydroxy-2-(methylthio)pyrimidine-5-carbonitrile-->3-OXO-3-THIOPHEN-2-YL-PROPIONIC ACID ETHYL ESTER-->5-AMINOPYRIMIDINE-->5-Bromo-2-(methylthio)pyrimidine-4-carboxylic acid-->ethyl 2-(methylsulfanyl)-4-(trifluoromethyl)pyrimidine-5-carboxylate-->4-Methoxy-6-methyl-2-(methylthio)pyrimidine-->4-METHYL-2-METHYLSULFANYL-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER-->2-(METHYLSULFANYL)-5-PHENYLPYRIMIDINE-->5-Methyl-2-(methylsulfonyl)pyrimidine ,97%-->Aminoguanidinium sulphate-->2-(METHYLTHIO)ETHANOL-->1-(4-METHYL-2-(METHYLTHIO)PYRIMIDIN-5-YL)ETHANONE-->Gabexate mesylate-->4-AMINO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBOXYLIC ACID-->ETHYL 2-(ETHYLTHIO)-4-HYDROXYPYRIMIDINE-5-CARBOXYLATE-->5-METHYL-2-METHYLSULFANYL-PYRIMIDINE
Chloromethyl isopropyl carbonate Neomycin sulfate Tetramethylthiourea Isobutyl methacrylate sulfate Ferric sulfate ISOFENPHOS-METHYL Albuterol sulfate SODIUM SULFATE 2-Methyl-2-thiopseudourea sulfate FERROUS SULFATE Ferrous sulfate monohydrate Atropine sulfate Colistin sulfate Magnesium sulfate Ammonium sulfate Magnesium sulfate heptahydrate Potassium sulfate
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