4-MALEIMIDOBUTYRIC ACID

4-MALEIMIDOBUTYRIC ACID Basic information
Product Name:4-MALEIMIDOBUTYRIC ACID
Synonyms:γ-Maleimidobutyric acid, 4-Maleimidobutanoic acid, N-(3-Carboxypropyl)maleimide, N-Maleoyl-4-aminobutyric acid, N-Maleoyl-GABA;4-Maleimidobutyric acid,γ-Maleimidobutyric acid, 4-Maleimidobutanoic acid, N-(3-Carboxypropyl)maleimide, N-Maleoyl-4-aminobutyric acid, N-Maleoyl-GABA;2,5-Dihydro-2,5-dioxo-1H-pyrrole-1-butanoic Acid;2-Cyclopropyl-5,6,7,8-tetrahydropyrido[4,3-d]pyriMidine hydrochloride;MBA 4-Maleimidobutyric acid;omega-Maleimidobutyric acid;4-(2,5-dioxo-2H-pyrrol-1(5H)-yl)butanoic acid;RARECHEM AL CD 0913
CAS:57078-98-5
MF:C8H9NO4
MW:183.16
EINECS:611-461-8
Product Categories:MTS & Sulfhydryl Active Reagents;Maleimide Derivatives;Nitric Oxide Reagents;Cross Linking Reagents
Mol File:57078-98-5.mol
4-MALEIMIDOBUTYRIC ACID Structure
4-MALEIMIDOBUTYRIC ACID Chemical Properties
Melting point 95-98 °C
Boiling point 400.1±28.0 °C(Predicted)
density 1.395±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Very Slightly)
form Solid
pka4.59±0.10(Predicted)
color White to Pale Yellow
BRN 1455876
CAS DataBase Reference57078-98-5(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
10-21
HS Code 29251900
MSDS Information
ProviderLanguage
SigmaAldrich English
4-MALEIMIDOBUTYRIC ACID Usage And Synthesis
Description4-(2,5-dioxo-2H-pyrrol-1(5H)-yl)butanoic acid contains a maleimide group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.
Chemical PropertiesWhite Solid
Uses
  1. A short crosslinking reagent
  2. Modification reagent for thiol groups in proteins
  3. Maleimide Derivatives
  4. MTS & Sulfhydryl Active Reagents
Uses4-Maleimidobutyric Acid is a short crosslinking reagent.
4-MALEIMIDOBUTYRIC ACID Preparation Products And Raw materials
Raw materialsEthyl acetate-->PETROLEUM ETHER-->Maleic anhydride-->4-Aminobutyric acid-->Maleimide
3-Maleimidobenzoic acid N-hydroxysuccinimide ester N-[4-(-Carboxycyclohexylmethyl)]maleimide GMBS 6-Maleimidocaproic acid N-Succinimidyl 3-maleimidopropionate 4-Maleimidobutyric Acid-NHS(GMBS) 4-Aminobutyric acid Γ-MALEIMIDOBUTYRIC ACID 4-Maleimidobutyric Acid hydrazide(GMBH) SULFO-GMBS 4-MALEIMIDOBUTYRIC ACID HYDRAZIDE N-Ethylmaleimide Maleimide 4-MALEIMIDOBUTYRIC ACID 4-Maleimidobutyric Acid(GMBA) N-Butylmaleimide N-N-BUTYLACRYLAMIDE N-PROPYLMALEIMIDE

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