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| | Firocoxib Basic information |
| | Firocoxib Chemical Properties |
| Melting point | 78-80°C | | Boiling point | 563.9±50.0 °C(Predicted) | | density | 1.31 | | storage temp. | Sealed in dry,Store in freezer, under -20°C | | solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) | | form | Solid | | color | White to Off-White | | InChI | InChI=1S/C17H20O5S/c1-17(2)14(12-6-8-13(9-7-12)23(3,19)20)15(16(18)22-17)21-10-11-4-5-11/h6-9,11H,4-5,10H2,1-3H3 | | InChIKey | FULAPETWGIGNMT-UHFFFAOYSA-N | | SMILES | O1C(C)(C)C(C2=CC=C(S(C)(=O)=O)C=C2)=C(OCC2CC2)C1=O |
| | Firocoxib Usage And Synthesis |
| Description | Firocoxib is a selective inhibitor of COX-2 (IC50s = 0.13 and 7.5 μM for COX-2 and COX-1, respectively, in isolated cat blood). It inhibits LPS-induced production of prostaglandin E2 (PGE2; ) in isolated dog, horse, and cat whole blood ex vivo. Firocoxib decreases lameness, induces analgesia, and improves range of motion in dogs and horses with osteoarthritis when administered at doses of 5 and 0.1 mg/kg per day, respectively. Formulations containing firocoxib have been used in dogs and horses with osteoarthritis. | | Chemical Properties | White Solid | | Uses | antibacterial | | Uses | A selective cyclooxygenase-2-(COX-2) inhibitor. Anti-inflammatory; analgesic. | | Definition | ChEBI: An enol ether that is the cyclopropylmethyl ether of 3-hydroxy-5,5-dimethyl-4-[4-(methylsulfonyl)phenyl]furan-2-one. A selective cyclooxygenase 2 inhibitor, it is used in veterinary medicine for the control of pain and inflammation associated with osteoart
ritis in horses and dogs. | | Brand name | Equioxx (Merial). | | Veterinary Drugs and Treatments | Firocoxib is indicated in dogs and horses for the control of pain
and inflammation associated with osteoarthritis. A chewable tablet
form for dogs and an oral paste for horses are available.
Like other NSAIDs, firocoxib can be useful for treating fever,
pain, and/or inflammation associated with other conditions, postsurgery,
trauma, etc.
Firocoxib may also be useful in other species, but information is
scant regarding its safety and efficacy. One study in cats (McCann,
Rickes et al. 2005) evaluating firocoxib in experimentally induced
pyrexia, demonstrated that the drug was effective after a single
oral dose in preventing or attenuating pyrexia at all doses studied
(0.75 – 3 mg/kg). |
| | Firocoxib Preparation Products And Raw materials |
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