4-Hydroxyaniline hydrochloride

4-Hydroxyaniline hydrochloride Basic information
Product Name:4-Hydroxyaniline hydrochloride
Synonyms:ci76551;durafurbrownr;fouraminecp;fourrine83;fourrinep;FurBrownp;furrop;futraminep
CAS:51-78-5
MF:C6H8ClNO
MW:145.59
EINECS:200-122-6
Product Categories:
Mol File:51-78-5.mol
4-Hydroxyaniline hydrochloride Structure
4-Hydroxyaniline hydrochloride Chemical Properties
Melting point 302 °C
Boiling point 306°C (decomp)
storage temp. Store below +30°C.
solubility DMSO (Slightly), Methanol (Slightly)
form powder
color gray
Water Solubility soluble
Merck 14,462
BRN 3911747
Stability:Stable, but hygroscopic, air and light sensitive. Incompatible with strong oxidizing agents.
CAS DataBase Reference51-78-5(CAS DataBase Reference)
EPA Substance Registry System4-Aminophenol hydrochloride (51-78-5)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38-43
Safety Statements 28-36
WGK Germany 3
RTECS SJ6070000
HS Code 29222900
Hazardous Substances Data51-78-5(Hazardous Substances Data)
ToxicityLD50 slt-dmg-orl: 750 mg/kg NTIS** AD691-490
MSDS Information
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4-Hydroxyaniline hydrochloride English
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4-Hydroxyaniline hydrochloride Usage And Synthesis
Chemical PropertiesOff white powder
Uses4-Aminophenol may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations using surface enhanced Raman scattering method.
General DescriptionPharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. 4-Aminophenol hydrochloride can be used to study cell biology, bioactive small molecules, chemical synthesis, organic building blocks, oxygen compounds and phenols.
Safety ProfileModerately toxic byintraperitoneal route. Mutation data reported. Whenheated to decomposition it emits very toxic fumes of HCland NOx.
Purification MethodsPurify the salt by treating an aqueous solution with saturated Na2S2O3, filtering under N2, then recrystallising it from 50% EtOH twice and once from absolute EtOH [Livingston & Ke J Am Chem Soc 72 909 1950]. [Beilstein 13 III 993.]
4-Hydroxyaniline hydrochloride Preparation Products And Raw materials
Raw materials5-amino-2-hydroxybenzenesulphonic acid-->Phenol-->Hydrochloric acid-->4-Nitrophenol-->4-Aminophenol
Preparation Products1-(4-HYDROXYPHENYL)-2-THIOUREA-->METHYL 5-AMINOSALICYLATE-->Chloromethane
4-[1-(hydroxyamino)ethylidene]cyclohexa-2,5-dien-1-one 3-ACETYL-4-HYDROXYANILINE HYDROCHLORIDE 2-AMINOPHENOL HYDROCHLORIDE 2,4-Dichloro-3-ethyl-6-aminophenol hydrochloride 3,5-dichloro-4-ethyl –2- hydroxyaniline hydrochloride 2,4-Dichloro-3-aminophenol hydrochloride ACETAMINOPHEN-D3 AcetaMidophen glucuronide-13C6 3-(N-ACETYL-L-CYSTEIN-S-YL) ACETAMINOPHEN, SODIUM SALT Acetaminophen Impurity B ACETAMINOPHEN IMPURITY B Acetaminophen-d3 mercapturate 4,4'-Iminodiphenol hydrochloride 4-ACETAMIDOPHENYL B-D-GLUCURONIDE-D3 3-HYDROXYACETAMINOPHEN 1,4-Benzoquinoneimine 4-Acetaminophen-d3 Sulfate Potassium Salt Paracetamol (Acetaminophen) EP Impurity L

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