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| | Hydroxymetronidazole Basic information |
| | Hydroxymetronidazole Chemical Properties |
| Melting point | 118-121°C | | Boiling point | 321.89°C (rough estimate) | | density | 1.4796 (rough estimate) | | refractive index | 1.5800 (estimate) | | storage temp. | -20°C Freezer | | solubility | DMSO (Sparingly), Methanol (Slightly) | | form | neat | | pka | 13.28±0.10(Predicted) | | color | White to Light Beige |
| Safety Statements | 24/25 | | WGK Germany | 3 | | RTECS | NI5568000 | | HS Code | 29332900 |
| | Hydroxymetronidazole Usage And Synthesis |
| Description | Hydroxy metronidazole is a metabolite of metronidazole. Metronidazole belongs to the nitroimidazole class of drugs. In agricultural production, it is often used as a drug to expel parasites in animals. After being added to animal feed, metronidazole remains in eggs. Because metronidazole has a variety of toxic and side effects on the human body, especially its potential carcinogenicity and hereditary mutation effects, and metronidazole can be rapidly distributed throughout the body after entering the human body, so the residual metronidazole and its metabolites in eggs inspection is necessary. | | Chemical Properties | Off-White Solid | | Uses | Hydroxymetronidazole (Metronidazole-OH) is a metabolite of Metronidazole belonging to the class of nitroimidazoles. Hydroxymetronidazole can be used for the research of certain bacterial and protozoal diseases in poultry, swine dysentery and genital trichomoniasis in cattle. | | Definition | ChEBI: Metronidazole-OH is a member of imidazoles and a C-nitro compound. | | Biological Activity | Hydroxymetronidazole is an active metabolite of the antibiotic metronidazole (Item No. 9002409). It is formed from metronidazole primarily by the cytochrome P450 (CYP) isoform CYP2A6. Hydroxymetronidazole is active against B. fragilis, B. thetaiotaomicron, B. distasonis, and B. ovatus (MICs = 1, 2, 1, and 2 μg/ml, respectively). It has been found in pork and porcine plasma. |
| | Hydroxymetronidazole Preparation Products And Raw materials |
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