ChemicalBook Product Catalog Chemical Reagents Organic reagents Esters Methyl ester compound Methyl isonipecotate

Methyl isonipecotate

Methyl isonipecotate Basic information
Product Name:Methyl isonipecotate
Synonyms:METHYL ISONIPECOTATE;ISONIPECOTIC ACID, METHYL AND ETHYL ESTERS;4-PIPERDINECARBOXYLIC ACID, METHYL ESTER;4-PIPERIDINECARBOXYLIC ACID METHYL ESTER;Methyl Piperidinecarboxylate;Ethyl nipecotate hydrochloride(Ethyl 3-Piperidinecarboxylate hydrochloride);Methyl Isonipecotate hydrochloride (Methyl 4-Piperidinecarboxylate hydrochloride);Methyl Isonipecotate(Methyl Piperidinecarboxylate)
CAS:2971-79-1
MF:C7H13NO2
MW:143.18
EINECS:629-683-9
Product Categories:Heterocycles;Intermediates;Miscellaneous Reagents;pharmacetical;Piperidine
Mol File:2971-79-1.mol
Methyl isonipecotate Structure
Methyl isonipecotate Chemical Properties
Boiling point 85-90 °C (lit.)
density 1.06 g/mL at 25 °C (lit.)
refractive index 1.465
Fp 192°F
storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility Chloroform
form Liquid
pka9.78±0.10(Predicted)
color Colorless to yellow
Water Solubility Slightly soluble in water.
CAS DataBase Reference2971-79-1(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
RIDADR 3267
WGK Germany 3
HS Code 29333990
MSDS Information
ProviderLanguage
4-Piperidinecarboxylic acid methyl ester English
Methyl isonipecotate Usage And Synthesis
Chemical PropertiesColorless liquid
UsesMethyl piperidine-4-carboxylate is a reactant for C-2 arylation of piperidines through directed transition metal-catalyzed sp3 C-H activation. It is used as a reactant for synthesis of antitubercular agents, aminopyrazine inhibitors, orally available naphthyridine protein kinase D inhibitors and a scalable catalyst from asymmetric hydrogenation of sterically demanding aryl enamide.
Uses4-Piperidinecarboxylic acid methyl ester is a an ester derivative of 4-piperidinecarboxylic acid used as a reagent in the organic synthesis of neurochemicals, antibacterials and other biologically active compounds.
UsesMethyl isonipecotate may be used for the synthesis of a series of potent non-urea soluble epoxide hydrolase (sEH) inhibitors via high throughput screens.
General DescriptionMethyl isonipecotate can be obtained by the reduction of methyl isonicotinate in methanol with ruthenium at 100-150°C.
Methyl isonipecotate Preparation Products And Raw materials
Preparation Products4-N-BOC-Aminopiperidine-->4-(3-ISOPROPYL-1,2,4-OXADIAZOL-5-YL)PIPERIDINE-->Benzyl 4-(chlorocarbonyl)tetrahydro-1(2H)-pyridinecarboxylate-->TERT-BUTYL 9-OXO-3-AZASPIRO[5.5]UNDECANE-3-CARBOXYLATE-->2-(4-PIPERIDYL)-2-PROPANOL-->N-METHYL-4-PIPERIDINECARBOXYLIC ACID METHYL ESTER-->1-(2-CYANOPHENYL)-4-PIPERIDINECARBOXYLIC ACID-->4-Piperidinecarboxylic acid, 1-[(4-methoxyphenyl)methyl]-, methyl ester-->METHYL 1-(4-NITROPHENYL)-4-PIPERIDINECARBOXYLATE-->N-Boc-Piperidine-4-carboxylic acid methyl ester-->Hexahydroisonicotinamide
AZINPHOS-METHYL ethyl 1-[(3-hydroxy-6-oxo-1(6H)-pyridazinyl)methyl]-4-piperidinecarboxylate Methyl NORMEPERIDINE ETHYL 1-[(6-CHLORO-3-PYRIDINYL)METHYL]-4-PIPERIDINECARBOXYLATE TERT-BUTYL 2[[3-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)PHENOXY]METHYL]PIPERIDINE-1-CARBOXYLATE (S)-TERT-BUTYL-2((((9H-FLUOREN-9-YL)METHOXY)CARBONYLAMINO)METHYL)PIPERIDINE-1-CARBOXYLATE Methy1--tert-Butoxycarbonyl-Piperidine-4-carboxylate METHYL 2S,3R-2-METHYL-PIPERIDINE-3-CARBOXYLATE 1-BENZYL-3-OXO-PIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER Methyl 1-tert-Butoxycarbonyl-Piperidine-2-carboxylate ETHYL 1-METHYL-2-PIPERIDINECARBOXYLATE Methyl 1-benzyl-4-oxo-3-piperidinecarboxylate hydrochloride ,95% Methyl isonipecotate Methyl piperidine-4-carboxylate, N-BOC protected ETHYL 1-METHYL-4-PIPERIDINECARBOXYLATE ethyl 1-((pyridin-4-yl)methyl) piperidine-4-carboxylate (R)-3-Methyl piperidridinelarbocxylate HCl
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