Bosutinib Impurity 2 (N-Desmethyl Bosutinib) Chemical Properties
Melting point
123-125 °C
Boiling point
655.4±55.0 °C(Predicted)
density
1.38±0.1 g/cm3(Predicted)
pka
9.19±0.10(Predicted)
Safety Information
MSDS Information
Bosutinib Impurity 2 (N-Desmethyl Bosutinib) Usage And Synthesis
Uses
Proteolysis Targeting Chimera (PROTAC) is a novel approach to modern drug development programs that utilizes small compounds to target proteins for ubiquitination and degradation by proteasome. 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(1-piperazinyl)propoxy]-3-quinolinecarbonitrile is a PROTAC compound, which has the potential to target oncogenic BCR-ABL for degradation. 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(1-piperazinyl)propoxy]-3-quinolinecarbonitrile has also been employed in ligand-based pharmacophore modelling to identify c-Src inhibitors.
Bosutinib Impurity 2 (N-Desmethyl Bosutinib) Preparation Products And Raw materials
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