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| | SULFACHLOROPYRIDAZINE Chemical Properties |
| Melting point | 186-187℃ | | Boiling point | 559.7±60.0 °C(Predicted) | | density | 1.588 | | refractive index | 1.6300 (estimate) | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | solubility | 0.5 M NaOH: soluble50mg/mL | | pka | pKa 6.10 (Uncertain) | | form | powder | | color | off-white to light yellow | | BRN | 261558 | | EPA Substance Registry System | Benzenesulfonamide, 4-amino-N-(6-chloro-3-pyridazinyl)- (80-32-0) |
| Hazard Codes | Xi | | Risk Statements | 43 | | Safety Statements | 36/37 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 2935909550 |
| | SULFACHLOROPYRIDAZINE Usage And Synthesis |
| Description | It is a sulfonamide antibiotic that is usually used as antibacterial anti-inflammatory drug, which has been applied in the treatment of acute urinary tract infections in childhood. Specifically, due to its antibiotic activity, this chemical has been selected as an ingredient to prepare antibacterial composition.1 Moreover, this substance can be introduced in the drinking water to fabricate aqueous liquid formulations for combating bacterial and protozoal in animals.2 In addition, this compound can act as an eco-friendly inhibitor for corrosion of mild steel in H2SO4 solution.3 Besides, sulfachloropyridazine associated to tripelennamine hydrocholoride has been demonstrated to function as an anti-stress agent in poultry after vaccinations.4
| | Brand Name(s) in US | Vetisulid
| | Reference |
- Stolar, M. E., Synergistic antibacterial composition US Patent 4470978 1984.
- Gerhard Lukas; Atasoy, K., Aqueous liquid formulations for control of bacterial and protozoal diseases US Patent 4423043 1983.
- Omar A. Hazazi; Ahmed Fawzy; Awad, M. I., Sulfachloropyridazine as an Eco-Friendly Inhibitor for Corrosion of Mild Steel in H2SO4 Solution Chemical Science Review and Letters 2015, 4, 67-79.
- M. Nakano; M.N. Narimatsu; Portugal, M. A. S. C., Use of sulfachloropyridazine associated to tripelennamine hydrochloride as anti-stress agent in poultry after vaccinations. Biologico 1977.
| | Originator | Sonilyn,Mallinckrodt Inc.,US,1962 | | Uses | Sulfachloropyridazine is an antibacterial compound.This compound is a contaminant of emerging concern (CECs). | | Definition | ChEBI: A sulfonamide antimicrobial used for urinary tract infections and in veterinary medicine. | | Manufacturing Process | 1.9 parts of 3,6-dichloropyridazine, 3.4 parts of sulfanilamide, 2.7 parts of
potassium carbonate and 1 part of sodium chloride were ground together. The
solid mixture was heated with stirring and as the dichloropyridazine and
sulfanilamide melted, the mixture became a slurry. When the bath
temperature had reached 140°C a sudden evolution of carbon dioxide
occurred which lasted about 5 minutes, after which the mixture set in fine
granules. When no more carbon dioxide was evolved, heating was stopped
and the reaction mixture was heated with sufficient water to dissolve it and
the solution allowed to cool. Unreacted sulfanilamide was collected by
filtration. Excess dichloropyridazine was removed from the filtrate by
extraction with a water immiscible organic solvent such as ether.
The basic solution was chilled and poured into one-half volume of 1:3 acetic
acid. Sufficient hydrochloric acid was added to bring the mixture to pH 4. The
crude 3-sulfanilamido-6-chloropyridazine which precipitated was purified by
solution in 6 parts of 1:100 ammonium hydroxide, charcoal treatment and
precipitation by pouring of the filtrate into dilute acetic acid. | | Brand name | Nefrosul (3M Pharmaceuticals); Sonilyn,(Carter-Wallace); Vetisulid [Veterinary] (Fort Dodge Animal Health). | | Therapeutic Function | Antibacterial |
| | SULFACHLOROPYRIDAZINE Preparation Products And Raw materials |
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