(R)-4-Boc-Piperazine-3-carboxylic acid

(R)-4-Boc-Piperazine-3-carboxylic acid Basic information

Product Name:	(R)-4-Boc-Piperazine-3-carboxylic acid
Synonyms:	1-BOC-PIPERAZINE-2-(R)-CARBOXYLIC ACID;(R)-PIPERAZINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER;(R)-1-(TERT-BUTOXYCARBONYL)PIPERAZINE-2-CARBOXYLIC ACID;(R)-1-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID;(R)-1-Boc-piperazine-2-carboxylic acid;(R)-4-Boc-Piperazine-3-carboxylicacid;N-Boc-piperazine-2-carboxylic acid;1,2-Piperazinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2R)-
CAS:	278788-60-6
MF:	C10H18N2O4
MW:	230.26
EINECS:
Product Categories:	amino acids;pharmacetical;Piperaizine
Mol File:	278788-60-6.mol

(R)-4-Boc-Piperazine-3-carboxylic acid Chemical Properties

Melting point	243-247 ºC (DEC.)
Boiling point	371.8±37.0 °C(Predicted)
density	1.193±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,2-8°C
pka	2.90±0.20(Predicted)
form	solid
color	White
CAS DataBase Reference	278788-60-6(CAS DataBase Reference)

Safety Information

MSDS Information

(R)-4-Boc-Piperazine-3-carboxylic acid Usage And Synthesis

Uses	(R)-1-Boc-Piperazine-2-carboxylic Acid is used in preparation of pyridoisoquinolines as VAMT2 inhibitors for the treatment of hyperkinetic disorders.

(R)-4-Boc-Piperazine-3-carboxylic acid Preparation Products And Raw materials

Raw materials	Ethanol-->Sodium hydroxide-->Hydrochloric acid-->Methanol-->Palladium-->1,4-Dioxane-->Di-tert-butyl dicarbonate-->N,N-Diisopropylethylamine-->Benzyl chloroformate-->(1R)-(-)-10-Camphorsulfonic acid-->Piperazine-2-carboxylic acid dihydrochloride-->(R)-(+)-2-Piperazinecarboxylic acid dihydrochloride
Preparation Products	(R)-1-(tert-butoxycarbonyl)-4-methylpiperazine-2-carboxylic acid

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