POBN

POBN Basic information
Product Name:POBN
Synonyms:α-(4-Pyridyl N-oxide)-N-tert-butylnitrone,N-(4-Pyridylmethylene)-tert-butylamine N,N′-dioxide, N-tert-Butyl-α-(4-pyridyl)nitrone N′-oxide, POBN;alpha-(4-Pyridyl 1-oxide)-N-tert-butyl-nitrone, 99% 100MG;N-tert-Butyl-α-(4-pyridyl)nitrone Nμ-oxide;POBN, N-tert-Butyl-α-(4-pyridyl)nitrone Nμ-oxide, N-(4-Pyridylmethylene)-tert-butylamine N,Nμ-dioxide;2-Methyl-N-[(pyridine 1-oxide)-4-ylmethylene]-2-propanamine oxide;4-Pyridyl-1-oxide-tert-butyl Nitrone;N-[(Pyridine 1-oxide)-4-ylmethylene]-tert-butylamineN-oxide;N-[[(Pyridine-1-oxide)-4-yl]methylene]-1,1-dimethylethanamine-N-oxide
CAS:66893-81-0
MF:C10H14N2O2
MW:194.23
EINECS:266-512-3
Product Categories:Analytical Chemistry;ESR Spectrometry;Spin Trapping Reagents;Analytical Reagents;Analytical/Chromatography;Building Blocks;C10;Chemical Synthesis;Electron Spin Resonance (ESR/EPR) Spectroscopy;Heterocyclic Building Blocks;Pyridines;Spectroscopy
Mol File:66893-81-0.mol
POBN Structure
POBN Chemical Properties
Melting point 183-185 °C(lit.)
Boiling point 330.68°C (rough estimate)
density 1.1444 (rough estimate)
refractive index 1.5000 (estimate)
storage temp. room temp
solubility water: soluble10mg/mL, clear, colorless to faintly yellow
form White to off-white or colorless crystalline solid.
pka0.76±0.53(Predicted)
color White to Light yellow
BRN 1453764
Safety Information
Safety Statements 22-24/25
WGK Germany 3
HS Code 29333999
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
POBN Usage And Synthesis
Chemical Propertieswhite to pale yellow crystalline powder
UsesSpin trap reagent used to measure ethanol oxidation to 1-hydroxyethyl radical (HER) which can bind to protein. Has also been used in studies of DNA methylation, iron-mediated polyunsaturated fatty acid peroxidation, and free-radical formation by Alzheimer β-amyloid peptide. The formation of hydroxyl radical in chondrocytes and cartilage has been detected using POBN.
UsesPOBN is a cell permeable hydrophilic spin trap for in vitro studies. It is a water soluble analog of PBN with low paramagnetic impurities and does not require any further purification. POBN has also also been used in studies of DNA methylation, iron-mediated polyunsaturated fatty acid peroxidation, and free-radical formation by Alzheimer β-amyloid peptide.
POBN Preparation Products And Raw materials
Preparation Products4-PYRIDINECARBOXALDEHYDE N-OXIDE
1-Hydroxy-2,2,6,6-tetramethyl-4-oxopiperidine 4,4'-DIPYRIDYL DISULFIDE 4-Picoline-N-oxide isonicotinaldehyde oxime 1-oxide POBN 4-Pyridinealdoxime

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