3-Picoline-N-oxide

3-Picoline-N-oxide Basic information

Product Name:	3-Picoline-N-oxide
Synonyms:	3-Methylpyridin-N-oxid;BETA-PICOLINE-N-OXIDE;3-Methylpyrine-N-Oxide;3-methyl-pyridin1-oxide;3-Picoline, 1-oxide;3-picoline-oxide;beta-Picoline 1-oxide;N-oxideof3-methylpyridine
CAS:	1003-73-2
MF:	C6H7NO
MW:	109.13
EINECS:	213-714-4
Product Categories:	Heterocyclic Compounds;Pyridines;Building Blocks;C6;Chemical Synthesis;Heterocyclic Building Blocks;Pyridine;Aromatics;Heterocycles;Intermediates
Mol File:	1003-73-2.mol

3-Picoline-N-oxide Chemical Properties

Melting point	37-39 °C(lit.)
Boiling point	150 °C15 mm Hg(lit.)
density	1.13
refractive index	1.5444 (estimate)
Fp	>230 °F
storage temp.	Sealed in dry,Room Temperature
solubility	>2000g/l
pka	pK1:10.921(+1) (25°C)
form	Crystalline Low Melting Mass
color	Pale yellow to brown
Water Solubility	soluble
Sensitive	Hygroscopic
BRN	106327
CAS DataBase Reference	1003-73-2(CAS DataBase Reference)
NIST Chemistry Reference	Pyridine, 3-methyl-, 1-oxide(1003-73-2)
EPA Substance Registry System	Pyridine, 3-methyl-, 1-oxide (1003-73-2)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-37/39-24/25-36
WGK Germany	1
RTECS	UT5799000
F	3-10
TSCA	Yes
HS Code	29333990
Toxicity	mouse,LD50,intraperitoneal,1689mg/kg (1689mg/kg),Toxicon. Vol. 23, Pg. 815, 1985.

MSDS Information

Provider	Language
3-Methylpyridine-N-oxide	English
SigmaAldrich	English
ACROS	English
ALFA	English

3-Picoline-N-oxide Usage And Synthesis

Chemical Properties	PALE YELLOW TO BROWN CRYSTALLINE LOW MELTING MASS
Uses	An intermediate in the preparation of nicotine derivatives.
Purification Methods	Purify the N-oxide by careful fractionation in vacuo. The distillate remains supercooled for several days before solidifying. It is a slightly hygroscopic solid which could melt in the hand. The picrate has m 149-151o (from EtOH). [Taylor & Corvetti Org Synth Coll Vol IV 654 1963, IR: Katritzky et al. J Chem Soc 3680 1959, Jaffé & Doak J Am Chem Soc 77 4441, 4481 1955, Boekelheide & Linn J Am Chem Soc 76 1286 1954]. [Beilstein 20 III/IV 2719, 20/5 V 517.]

3-Picoline-N-oxide Preparation Products And Raw materials

Raw materials	Hydrogen peroxide-->3-Picoline
Preparation Products	2-Amino-5-methylpyridine-->2-Chloro-5-methylpyridine-->Admire-->4-Bromo-3-methylpyridine-->3-Methylpyridine-2-carboxylic acid-->4-Nitro-3-picoline N-oxide-->4(1H)-Pyridinimine, 3-methyl--->4-Acetamidonicotinic acid-->Acetamide, N-(3-methyl-4-pyridinyl)- (9CI)-->4-methoxy-3-methylpyridine N-oxide

1-(1-OXIDO-3-PYRIDINYL)ETHANOL 2-Chloro-5-chloromethylpyridine Iron oxide (1-OXIDO-3-PYRIDINYL)(PHENYL)METHANOL 3-[(PROP-2-YNYLOXY)CARBONYL]PYRIDINIUM-1-OLATE 3-PYRIDINEMETHANOL N-OXIDE 3-Aminopyridine 3-METHYLQUINOLINE N-OXIDE 2-PHENOXY-3-(([2-(PHENYLSULFONYL)ETHYL]AMINO)CARBONYL)PYRIDINIUM-1-OLATE 3-Picoline-N-oxide 4-Nitro-2,3-lutidine-N-oxide 2,6-Lutidine 2,4,6-Collidine Nicotinamide-N-oxide 2,6-BIS[(4-CHLOROPHENYL)SULFONYL]-3-CYANO-4-METHYLPYRIDINIUM-1-OLATE 4-NITRO-3-PICOLINE N-OXIDE,4-Nitro-3-picoline 1-oxide,4-Nitro-beta-picoline N-oxide,4-Nitro-3-picoline-N-oxide 99%,4-Nitro-B-picoline N-oxide Nicotinic acid N-oxide Cuprous oxide

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