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OSELTAMIVIR ACID

OSELTAMIVIR ACID Basic information
Product Name:OSELTAMIVIR ACID
Synonyms:(3R,4R,5S)-4-acetamido-5-amino-3;Oseltamivir Phosphate Impurity Ⅲ;(3R,4R,5S)-4-(Acetylamino)-5-amino-3-(1-ethylpropoxy)-1-cyclohexence-1-carboxylic Acid;Oseltamivir Impurity C (EP);Oseltamivir Carboxylic Acid HCl;GS 4071;RO 64-0802;OSELTAMIVIR CARBOXYLATE;(3R,4R,5S)-4-acetamido-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid;(3R,4R,5S)-4-Acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohex-ene-1-carboxylic acid
CAS:187227-45-8
MF:C14H24N2O4
MW:284.35
EINECS:
Product Categories:Various Metabolites and Impurities;Metabolites;Amines;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
Mol File:187227-45-8.mol
OSELTAMIVIR ACID Structure
OSELTAMIVIR ACID Chemical Properties
Melting point 183-185°C
Boiling point 508.7±50.0 °C(Predicted)
density 1.15±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,2-8°C
solubility ≥14.2 mg/mL in DMSO; ≥46.1 mg/mL in H2O with gentle warming; ≥97 mg/mL in EtOH with gentle warming
form neat
pka4.13±0.60(Predicted)
EPA Substance Registry System1-Cyclohexene-1-carboxylic acid, 4-(acetylamino)-5-amino-3-(1-ethylpropoxy)-, (3R,4R,5S)- (187227-45-8)
Safety Information
HS Code 9999999999
MSDS Information
OSELTAMIVIR ACID Usage And Synthesis
DescriptionOseltamivir (GS-4104) is an antiviral prodrug targeted against the influenza viruses. Oseltamivir acid is the active metabolite of oseltamivir. It acts as an inhibitor of influenza neuraminidases A and B (IC50 = 0.1 to 4.9 nM for both enzymes), in this way preventing virus budding and release.
Chemical PropertiesWhite Solid
UsesOseltamivir Acid is a metabolite of Oseltamivir (O701000).
UsesOseltamivir Acid (Oseltamivir EP Impurity C) is a metabolite of Oseltamivir (O701000). It is a COVID19-related research product.
DefinitionChEBI: A cyclohexenecarboxylic acid that is cyclohex-1-ene-1-carboxylic acid which is substituted at positions 3, 4, and 5 by pentan-3-yloxy, acetamido, and amino groups, respectively (the 3R,4R,5S enantiomer). A antiviral drug, it is used as the corresponding ethyl ester prodrug, oseltamivir, to slow the spread of influenza.
references[1] enguang feng, deju ye, jian li, dengyou zhang, jinfang wang, fei zhao, rolf hilgenfeld, mingyue zheng, hualiang jiang and hong liu. recent advances in neuraminidase inhibitor development as anti-influenza drugs. chem med chem 2012, 7: 1527 – 1536.
[2] tom jefferson reviewer, mark jones, peter doshi, elizabeth a spencer, igho onakpoya, carl j heneghan. oseltamivir for influenza in adults and children: systematic review of clinical study reports and summary of regulatory comment. bmj. 2014, 348: g2545.
[3] rashmi dixit, gulam khandaker, scott ilgoutz, harunor rashid and robert booy. emergence of oseltamivir resistance: control and management of influenza before, during and after the pandemic. infectious disorders – drug targets. 2013, 13 (1): 34-45.
OSELTAMIVIR ACID Preparation Products And Raw materials
Oseltamivir EP Impurity E HCl Oseltamivir phosphate Oseltamivir EP Impurity A (3R,4R,5R)-3-(1-Ethylpropoxy)-4-hydroxy-5-[(Methylsulfonyl)oxy]-1-cyclohexene-1-carboxylic Acid Ethyl Ester Oseltamivir Impurity 17 OseltaMivir Acid Methyl Ester OseltaMivir IMpurity D ent-OseltaMivir Phosphate 4-N-Desacetyl-5-N-acetyl OseltaMivir 3-Des(1-ethylpropoxy)-3-(1-Methylpropoxy) OseltaMivir OSELTAMIVIR, [3H]- Oseltamivir OSELTAMIVIR MONO HYDROCHLORIDE OSELTAMIVIR-D3 PHOSPHATE OSELTAMIVIR ACID OSELTAMIVIR CITRATE OSELTAMIVIR ACID-D3
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