N-Methylolchloroacetamide

N-Methylolchloroacetamide Basic information
Product Name:N-Methylolchloroacetamide
Synonyms:2-chloro-N-(hydroxymethyl)acetamid;2-chloro-n-(hydroxymethyl)-acetamid;2-chloro-n-hydroxymethyl-acetamid;chloracetamide-n-metholol;n-methylol-chloracetamide;2-CHLORO-N-(HYDROXYMETHYL)ACETAMIDE;N-METHYLOLCHLOROACETAMIDE;N-HYDROXYMETHYL-2-CHLOROACETAMIDE
CAS:2832-19-1
MF:C3H6ClNO2
MW:123.54
EINECS:220-598-9
Product Categories:Amides;Carbonyl Compounds;Organic Building Blocks
Mol File:2832-19-1.mol
N-Methylolchloroacetamide Structure
N-Methylolchloroacetamide Chemical Properties
Melting point 100-105 °C(lit.)
Boiling point 374.0±27.0 °C(Predicted)
density 1.2776 (rough estimate)
refractive index 1.5000 (estimate)
storage temp. Inert atmosphere,2-8°C
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka12.63±0.46(Predicted)
color White to Off-White
Water Solubility Very soluble in water. Poorly soluble in aliphatic hydrocarbons.
Sensitive Hygroscopic
BRN 1811765
CAS DataBase Reference2832-19-1(CAS DataBase Reference)
EPA Substance Registry System2-Chloro-N-(hydroxymethyl)acetamide (2832-19-1)
Safety Information
Hazard Codes C
Risk Statements 34-43-40-20/21/22
Safety Statements 26-27-36/37/39-45
RIDADR UN 3261 8/PG 2
WGK Germany 3
RTECS AB5733000
TSCA Yes
HazardClass 8
PackingGroup 
HS Code 29241990
MSDS Information
ProviderLanguage
2-Chloro-N-(hydroxymethyl)acetamide English
SigmaAldrich English
ACROS English
ALFA English
N-Methylolchloroacetamide Usage And Synthesis
Chemical PropertiesWhite or almost white crystalline powder
Uses2-Chloro-N-(hydroxymethyl)acetamide (N-hydroxymethylchloroacetamide) may be used as a reagent in the synthesis of 1-(aminomethyl)-2-methoxynaphthalene hydrochloride and as a amidomethylating reagent for N,N-dialkylanilines (Tscherniac-Einhorn reaction).
UsesN-Methylolchloro-acetamide is a preservative in cooling fluids and cosmetics.
UsesAn organic building block. It is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals. As dyestuff intermediate .
General Description2-Chloro-N-(hydroxymethyl)acetamide (N-methylolchloracetamide) is a N-hydroxymethyl derivative of chloroacetamide. One of the method reported for its synthesis is by the reaction of 2-chloracetamide with formaldehyde. It has been reported to be a formaldehyde releaser and an infrequent sensitizer to formaldehyde contact allergy. Influence of short and prolonged exposure of 2-chloro-N-(hydroxymethyl)acetamide (as formaldehyde donor/releaser) on lymph node responses has been investigated. It has high biocide action and is utilized as preservative.
N-Methylolchloroacetamide Preparation Products And Raw materials
Preparation Products2-aminomethyl-4-t-butyl-6-iodophenol
4,5-DICHLORO-2-(HYDROXYMETHYL)-2,3-DIHYDROPYRIDAZIN-3-ONE (4,5-DICHLORO-6-OXO-1,6-DIHYDROPYRIDAZIN-1-YL)METHYL BENZOATE N-(HYDROXYMETHYL)ACETAMIDE 4,5-DICHLORO-2-(HYDROXYMETHYL)-6-NITRO-2,3-DIHYDROPYRIDAZIN-3-ONE Dichloroacetamide Alachlor (4,5-DICHLORO-6-OXO-1,6-DIHYDROPYRIDAZIN-1-YL)METHYL THIOPHENE-2-CARBOXYLATE Machette methylol cellulose Acetochlor DIACETAMIDE N-HYDROXYMETHYLTRICHLOROACETAMIDE Hydroxymethyl N-Methylolchloroacetamide 2,2,2-Trichloroacetamide (4,5-DICHLORO-6-OXO-1,6-DIHYDROPYRIDAZIN-1-YL)METHYL 2-(ETHYLTHIO)NICOTINATE Epichlorohydrin METHYL CHLOROACETYLCARBAMATE

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