7-METHYLGUANINE

7-METHYLGUANINE Basic information

Product Name:	7-METHYLGUANINE
Synonyms:	2-amino-1,7-dihydro-7-methyl-6h-purin-6-on;2-amino-1,7-dihydro-7-methyl-6h-purin-6-one;2-Amino-7-methyl-1,7-dihydro-6H-purin-6-one;2-Amino-7-methylhypoxanthine;6H-Purin-6-one, 2-amino-1,7-dihydro-7-methyl-;7-methyl-guanin;N7-Methylguanine;7-METHYLGUANINE
CAS:	578-76-7
MF:	C6H7N5O
MW:	165.15
EINECS:	209-431-0
Product Categories:	Amines;Bases & Related Reagents;Nucleic acids;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals
Mol File:	578-76-7.mol

7-METHYLGUANINE Chemical Properties

Melting point	370°C
Boiling point	292.98°C (rough estimate)
density	1.3629 (rough estimate)
refractive index	1.8500 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Aqueous Base (Slightly)
pka	9.78±0.20(Predicted)
form	Solid
color	Light Brown to Brown
BRN	174245

Safety Information

WGK Germany	3
RTECS	MF8464000
F	10-23

MSDS Information

Provider	Language
SigmaAldrich	English

7-METHYLGUANINE Usage And Synthesis

Uses	Has binding affinity to guanine deaminase, an important metalloenzyme in purine catabolism. Found in urine of patients with malignant cancer.
Definition	ChEBI: A 7-methylguanine that is 1,7-dihydro-6H-purin-6-one substituted by an amino group at position 2 and a methyl group at position 7.
Purification Methods	Crystallise it from water. UV: at 280nm (pH 2.1). The picrate has m 267o (270-272o dec, also reported). [Beilstein 26 H

7-METHYLGUANINE Preparation Products And Raw materials

Raw materials	Guanosine, 7-methyl-,inner salt (9CI)-->6-METHYLPURINE RIBOSIDE-->2'-Deoxyadenosine-->2'-DEOXYGUANOSINE 5'-MONOPHOSPHATE-->6-Methylthioguanine-->6-Methoxypurine-->7-METHYLGUANOSINE-->6-Methylpurine-->6-METHOXYPURINE RIBOSIDE-->Chloromethane-->Adenosine-->Trimethyl phosphate
Preparation Products	2-Amino-6-chloropurine-9-riboside-->O6-METHYL-2'-DEOXYGUANOSINE

AURORA 15074 MCAP AMMONIUM SALT ANTI-MGMT 8-Hydroxy-7-methylguanine 9-METHYLGUANINE,N9-Methylguanine 9-(1'-hydroxy-2'-(hydroxymethyl)ethoxy)methylguanine N-Acetyl-9-(2-acetylethoxy)methyl guanine 2-Amino-7-Benzyl-1H-Purin-6(7H)-One M7G(5')PPP(5')G, DILITHIUM SALT ring-opened-7-methylguanine DNA glycosylase Aciclovir sodium 7-METHYLGUANINE 8-METHYLGUANINE Acyclovir O6-METHYLGUANINE-DNA METHYLTRANSFERASE,O-6-METHYLGUANINE-DNA METHYLTRANSFERASE, HUMAN N2-METHYLGUANINE dichlorocyclohexyldiamine-9-methylguanine platinum IV 7-ethylguanine

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