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| | T-2 TOXIN Basic information |
| Product Name: | T-2 TOXIN | | Synonyms: | 4β,15-Diacetoxy-8α-(3-Methylbutyryloxy)-
12,13-epoxytrichothec-9-en-3α-ol;8α-(3-Methylbutyryloxy)-4β,15-
diacetoxyscirp-9-en-3α-ol;T-2 LienoMycin;T-2 Toxin, froM FusariuM tricinctuM;12,13-epoxytrichothec-9-ene-3-alpha,4-beta,8-alpha,15-tetrol4,15-diacetate8;12,13-trichothecene;3alpha-Hydroxy-4beta,15-diacetoxy-8alpha(3-methylbutyryloxy)-12,13-epoxy-trichothec-9-ene;3alpha-hydroxy-4beta-15-diacetoxy-8alpha-(3-methylbutyryloxy)-12,13-epoxy-delt | | CAS: | 21259-20-1 | | MF: | C24H34O9 | | MW: | 466.53 | | EINECS: | 244-297-7 | | Product Categories: | | | Mol File: | 21259-20-1.mol |  |
| | T-2 TOXIN Chemical Properties |
| Melting point | 151.5℃ | | alpha | D26 +15° (c = 2.58 in ethanol) | | Boiling point | 489.35°C (rough estimate) | | density | 1.1942 (rough estimate) | | refractive index | 1.6230 (estimate) | | Fp | 2 °C | | storage temp. | −20°C | | solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml; Ethanol: 20 mg/ml | | form | powder | | pka | 13.24±0.70(Predicted) | | color | white | | Merck | 13,9872 | | IARC | 3 (Vol. 31, Sup 7) 1987 |
| Hazard Codes | T+,T,Xn,F | | Risk Statements | 26/27/28-38-36-20/21/22-11 | | Safety Statements | 28-36/37-45-36-26-16-36/37/39-22 | | RIDADR | UN 3462 6.1/PG 1 | | WGK Germany | 3 | | RTECS | YD0100000 | | F | 10-21 | | HazardClass | 6.1(a) | | PackingGroup | I | | HS Code | 29329990 | | Hazardous Substances Data | 21259-20-1(Hazardous Substances Data) | | Toxicity | LD50 orally in female rats: 4.0 mg/kg (Marasas); LD50 (mg/kg) in mice: 5.2 i.p., 4.2 i.v.; in rats: 7.0 intragastric, 0.9-1.3 i.p., 0.9 i.v., 2.0 s.c.; in guinea pigs: 3.0-4.0 orally, 5.3 intragastric, 1.0 i.m., 1.0-2.0 i.v., 1.0-2.0 s.c.; in pigs: 5.0 orally, 3.0 i.v. (Yagen, Bailer) |
| | T-2 TOXIN Usage And Synthesis |
| Description | T-2 toxin is a trichothecene mycotoxin that has been found in Fusarium. It binds to and inhibits peptidyltransferase in the 60S ribosomal subunit, inducing a ribotoxic stress response that triggers JNK and p38 MAPK signaling. T-2 toxin (3 nM) decreases toll-like receptor expression and LPS-induced production of IL-1β, TNF-α, and nitric oxide (NO) in, and is cytotoxic to (IC50 = 19.47), primary pig alveolar macrophages (PAMs). In vivo, T-2 toxin induces production of reactive oxygen species (ROS), lipid peroxidation, and glutathione (GSH) depletion in mouse brain and is lethal to mice (LD50s = 1.54-5.94 mg/kg). It also induces hepatocyte apoptosis and dyslipidemias in mice. T-2 toxin has been found in Fusarium-infected wheat, barley, and rice crops both in fields and in storage. | | Chemical Properties | White powder | | Uses | T-2 Toxin is a tricothecene mycotoxin produced by fungi of the genus Fusarium. T-2 Toxin induces DNA damage and cell death on prolonged administration. | | Definition | ChEBI: T-2 toxin is a trichothecene mycotoxin produced by fungi of the genus Fusarium. It is a common contaminant in food and feedstuffs of cereal origin and is known to cause a range of toxic effects in humans and animals. It has a role as a mycotoxin, a cardiotoxic agent, a neurotoxin, an environmental contaminant, an apoptosis inducer, a DNA synthesis inhibitor and a fungal metabolite. It is a trichothecene, an acetate ester and an organic heterotetracyclic compound. It is functionally related to a HT-2 toxin. | | General Description | T-2 Toxin is found to be a potent trichothecene mycotoxin produced by the genus fusarium fungi in feedstuffs and cereal grains. | | Safety Profile | Poison by ingestion,
intramuscular, subcutaneous, intraperitoneal,
intracerebral, and intravenous routes.
Moderately toxic by inhalation.
Experimental teratogenic and reproductive
effects. A skin irritant. Questionable
carcinogen with experimental neoplastigenic
data. Mutation data reported. When heated
to decomposition it emits acrid smoke and
irritating fumes. |
| | T-2 TOXIN Preparation Products And Raw materials |
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