ALPHA-APO-OXYTETRACYCLINE

ALPHA-APO-OXYTETRACYCLINE Basic information
Product Name:ALPHA-APO-OXYTETRACYCLINE
Synonyms:ALPHA-APO-OXYTETRACYCLINE;BETA-APO-OXYTETRACYCLINE;Oxytetracycline Impurity 4(Oxytetracycline EP Impurity D);α-Apo-oxytetracycline, 'can be used as secondary standard;alpha-Apo-oxytetracycline, 'can be used as secondary standard';Cefamandole Sodium Impurity 5;4-(1,3-Dihydro-4,5-dihydroxy-9-Methyl-3-oxonaphtho[2,3-c]furan-1-yl)-3-(diMethylaMino)-2,5-dihydroxy-6-oxo-1-cyclohexene-1-carboxaMide;α-ApoterraMycin
CAS:18695-01-7
MF:C22H22N2O8
MW:442.42
EINECS:
Product Categories:Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
Mol File:18695-01-7.mol
ALPHA-APO-OXYTETRACYCLINE Structure
ALPHA-APO-OXYTETRACYCLINE Chemical Properties
Melting point 200°C
Boiling point 742.4±60.0 °C(Predicted)
density 1.62±0.1 g/cm3(Predicted)
storage temp. Refrigerator, Under Inert Atmosphere
solubility Aqueous Base (Slightly), Methanol (Slightly)
pka1.62±0.58(Predicted)
form Crystalline Powder
color Khaki
Stability:Hygroscopic, Unstable in basic solution
EPA Substance Registry System1-Cyclohexene-1-carboxamide, 4-(1,3-dihydro-4,5-dihydroxy-9-methyl-3-oxonaphtho[2,3-c]furan-1-yl)-3-(dimethylamino)-2,5-dihydroxy-6-oxo-, stereoisomer (18695-01-7)
Safety Information
HS Code 29413020
MSDS Information
ProviderLanguage
ACROS English
ALPHA-APO-OXYTETRACYCLINE Usage And Synthesis
Chemical Propertieskhaki-coloured crystalline powder
UsesOxytetracycline metabolite (absolute stereochemistry unknown)
Usesα-Apooxytetracycline is a degradation product of oxytetracycline, formed under acidic conditions. An initial dehydration to anhydrooxytetracycline then undergoes an internal cyclisation of the C5-OH to the C12 ketone. The resulting cleavage of the C12-C12a bond generates two isomers, α- and β-apooxytetracycline. α-apooxytetracycline is an important standard for monitoring oxytetracycline stability.
Usesα-Apooxytetracycline is a degradation product of oxytetracycline, formed under acidic conditions. After initial dehydration to anhydrooxytetracycline, it undergoes an internal cyclisation of the C5-OH to the C12 ketone. The resulting cleavage of the C12-C12a bond generates two isomers, α- and β-apooxytetracycline. α-Apooxytetracycline is an important standard for monitoring oxytetracycline stability.
ALPHA-APO-OXYTETRACYCLINE Preparation Products And Raw materials
1-Naphthalenol,6-methyl-(9CI) (1S,2S)-(+)-Pseudoephedrine hydrochloride 2-METHYL-1-PHENYL-1-PENTANOL METHYL 2-NAPHTHOATE 2-METHYL-2-CYCLOHEXEN-1-ONE cyclohex-1-ene-1-methylamine 1,2,3-TRIMETHYLNAPHTHALENE 5-PHENYL-1-PENTENE Hexyl salicylate 2,3-DIMETHYLNAPHTHALENE 3-BENZYLOXY-2-METHYL-1-PROPANOL ETHYL 2-NAPHTHOATE 3-NAPHTHALEN-2-YL-PROPAN-1-OL ALPHA-APO-OXYTETRACYCLINE 3-DIMETHYLAMINO-1-PHENYL-PROPAN-1-OL 3-OXO-PENTANOIC ACID AMIDE Isobutyl salicylate 5-Methylnaphthalene-1-ol

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