ChemicalBook Product Catalog Chemical Reagents Organic reagents Thiourea ETHYLTHIOUREA

ETHYLTHIOUREA

ETHYLTHIOUREA Basic information
Product Name:ETHYLTHIOUREA
Synonyms:1-ethyl-2-thio-ure;1-ETHYLTHIOUREA;1-ETHYL-2-THIOUREA;Ethylthiourea,99%;Thiourea, ethyl-;ETHYLTHIOUREA;N-ETHYLTHIOUREA, POLYMER-BOUND;N-ETHYL-2-THIOUREA
CAS:625-53-6
MF:C3H8N2S
MW:104.17
EINECS:210-899-3
Product Categories:Catalysis and Inorganic Chemistry;Metal Scavengers;MetalChemical Synthesis;Scavengers;Supported Synthesis
Mol File:625-53-6.mol
ETHYLTHIOUREA Structure
ETHYLTHIOUREA Chemical Properties
Melting point 108-110 °C(lit.)
Boiling point 132 °C
density 1.055 (estimate)
refractive index 1.5500 (estimate)
storage temp. Store at RT
solubility methanol: soluble25mg/mL, clear, colorless
form Solid
pka14.97±0.29(Predicted)
color White to Off-White
Water Solubility Soluble in water (24g/L).
BRN 1699551
InChIKeyGMEHFXXZSWDEDB-UHFFFAOYSA-N
CAS DataBase Reference625-53-6(CAS DataBase Reference)
EPA Substance Registry SystemEthylthiourea (625-53-6)
Safety Information
Hazard Codes T
Risk Statements 25
Safety Statements 36/37/39-45
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS YT3700000
TSCA Yes
HazardClass 6.1
PackingGroup III
Hazardous Substances Data625-53-6(Hazardous Substances Data)
Toxicitymouse,LDLo,oral,500mg/kg (500mg/kg),Teratology, The International Journal of Abnormal Development. Vol. 23, Pg. 335, 1981.
MSDS Information
ProviderLanguage
SigmaAldrich English
ALFA English
ETHYLTHIOUREA Usage And Synthesis
UsesN-Ethylthiourea was used in the preparation of Re (III) complexes, which are precursors for the new rhenium complexes, potentially useful in nuclear medicine. It was also used in two-step protocol for the first chemoselective cleavage of 2-hydroxy acid amides
DefinitionChEBI: N-ethylthiourea is a member of the class of thioureas that is thiourea in which one of the hydrogens is replaced by an ethyl group. It is functionally related to a thiourea.
General DescriptionN-Ethylthiourea forms adduct with silver halides and their single crystal X-ray structural and spectroscopic characterizations are described.
Biological ActivityPotent, selective and reversible inhibitor of isoform II NO synthase (IC 50 = 13 nM; approximately 20- and 30-fold selective over isoforms I and III respectively).
Safety ProfilePoison by ingestion. SYN: 1-ETHYLTHIOUREA Experimental teratogenic effects. Mutation data reported. When heated to decomposition it emits toxic fumes of Sox and NOx.
Purification MethodsCrystallise the thiourea from EtOH, MeOH or ether. [Beilstein 4 IV 374.]
ETHYLTHIOUREA Preparation Products And Raw materials
Preparation ProductsGuanidineacetic acid-->N-ethyl-5-methylthiazol-2-amine
1-BENZYL-3-METHYL-2-THIOUREA 4-METHYL-5-(TRIFLUOROMETHYL)-1,2,4-TRIAZOLIN-3(2H)-THIONE 2-THIOCYTIDINE 5,5-DIPHENYL-2-THIOHYDANTOIN N-(2,3-DICHLOROPHENYL)-N'-ETHYLTHIOUREA DITHIOURACIL N-(2-BROMOPHENYL)-N'-ETHYLTHIOUREA N-(2-AMINOPHENYL)-N'-ETHYLTHIOUREA N-(3,5-DIMETHYLPHENYL)-N'-ETHYLTHIOUREA N-{(1E)-(BENZYLAMINO)[(4,6-DIMETHYLPYRIMIDIN-2-YL)AMINO]METHYLENE}-N'-ETHYLTHIOUREA N-(2,4-DIMETHOXYPHENYL)-N'-ETHYLTHIOUREA N-CYCLOPENTYL-N'-ETHYLTHIOUREA 2-THIO-6-AZAURIDINE 1-CYCLOHEXYL-3-(2-MORPHOLINOETHYL)THIOUREA N-{(1E)-[(4,6-DIMETHYLPYRIMIDIN-2-YL)AMINO][(PYRIDIN-3-YLMETHYL)AMINO]METHYLENE}-N'-ETHYLTHIOUREA 1-ALLYL-3-(2-HYDROXYETHYL)-2-THIOUREA 5-(N'-[2-AMINOETHYL]THIOUREIDOFLUORESCEIN) N-[1-AZA-2-[2-[(4,6-DIMETHOXYTRIAZIN-2-YL)OXY]PHENYL]ETHEN-1-YL]-N'-ETHYLTHIOUREA
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