|
| | SCUTELLAREIN Basic information |
| | SCUTELLAREIN Chemical Properties |
| Melting point | 330°C | | Boiling point | 642.9±55.0 °C(Predicted) | | density | 1.654±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,2-8°C | | solubility | DMSO: soluble1mg/mL, clear, greenish-yellow | | pka | 6.34±0.40(Predicted) | | form | powder | | color | yellow | | InChIKey | JVXZRQGOGOXCEC-UHFFFAOYSA-N | | LogP | 2.540 (est) |
| Safety Statements | 24/25 | | WGK Germany | 3 | | HS Code | 29329990 |
| | SCUTELLAREIN Usage And Synthesis |
| Description | Scutellarein is a flavone that has been isolated from S. baicalensis and has antioxidant, enzyme inhibitory, anti-inflammatory, and antiproliferative biological activities. It has antioxidant activity in a total reactive antioxidant potential (TRAP) assay when used at a concentration of 1 μg/ml. Scutellarein inhibits sucrose hydrolysis by rat intestinal α-glucosidase and ATPase activity of the severe acute respiratory syndrome (SARS) coronavirus helicase nsP13 (IC50s = 12 and 0.86 μM, respectively). It decreases nitric oxide (NO) release and mRNA expression of inducible NO synthase (iNOS) and TNF-α induced by LPS in RAW 264.7 macrophages when used at a concentration of 50 μM. In vivo, scutellarein (0.5 μg/g) decreases tumor weight and volume in an HT-1080 human fibrosarcoma mouse xenograft model. | | Chemical Properties | Yellow solid | | Uses | Scutellarein is a flavonoid that can be found in Scutellaria lateriflora. Scutellarein is a hydrolysis product of Scutellarein (S201900), its glucuronide conjugated analogue. | | Definition | ChEBI: Flavone substituted with hydroxy groups at C-4', -5, -6 and -7. |
| | SCUTELLAREIN Preparation Products And Raw materials |
|
