1-Ethylpiperazine

1-Ethylpiperazine Basic information
Product Name:1-Ethylpiperazine
Synonyms:1-ethyl-piperazin;Piperazine, 1-ethyl-;ETHYLPIPERAZINE-N;LABOTEST-BB LTBB000704;1-ETHYLPIPERAZINE;N-ETHYLPIPERAZINE;NEPRZ;AKOS BBS-00003610
CAS:5308-25-8
MF:C6H14N2
MW:114.19
EINECS:226-166-6
Product Categories:Heterocyclic Building Blocks;Piperidines, Piperidones, Piperazines;Piperaizine;Piperazines;Building Blocks;Heterocyclic Building Blocks;Building Blocks;C4 to C8;Chemical Synthesis;bc0001;K00001
Mol File:5308-25-8.mol
1-Ethylpiperazine Structure
1-Ethylpiperazine Chemical Properties
Melting point -60 °C
Boiling point 157 °C(lit.)
density 0.899 g/mL at 25 °C(lit.)
vapor pressure 2.48hPa at 20℃
refractive index n20/D 1.469(lit.)
Fp 110 °F
storage temp. 2-8°C
solubility soluble
form Liquid
pka9.27±0.10(Predicted)
Specific Gravity0.899
color Clear colorless to yellow
Water Solubility soluble
Sensitive Air Sensitive
BRN 102971
InChIKeyWGCYRFWNGRMRJA-UHFFFAOYSA-N
LogP-0.1 at 20℃
CAS DataBase Reference5308-25-8(CAS DataBase Reference)
NIST Chemistry ReferenceN-ethylpiperazine(5308-25-8)
EPA Substance Registry SystemPiperazine, 1-ethyl- (5308-25-8)
Safety Information
Hazard Codes Xi,Hazard
Risk Statements 36/37/38-10
Safety Statements 26-36
RIDADR UN 1993 3/PG 3
WGK Germany 1
RTECS TM0815500
10-34
HazardClass 3
PackingGroup III
HS Code 29335995
MSDS Information
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1-Ethylpiperazine English
SigmaAldrich English
ACROS English
ALFA English
1-Ethylpiperazine Usage And Synthesis
Chemical Propertiesclear colorless to yellow liquid
Uses1-Ethylpiperazine is used in the synthesis of 2-(2-methoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1H-benzo[d]imidazole hydrochloride and 2-(5-((4-ethylpiperazin-1-yl)sulfonyl)-2-methoxyphenyl)-1H-benzo[d]imidazole hydrochloride. It is also employed as an intermediate in veterinary medicine, especially in the production of ciproflmoxacin ethyl. Further, it serves as a precursor to prepare dyes.
Uses1-Ethylpiperazine may be used in the preparation of 2-(2-methoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1H-benzo[d]imidazole hydrochloride and 2-(5-((4-ethylpiperazin-1-yl)sulfonyl)-2-methoxyphenyl)-1H-benzo[d]imidazole hydrochloride.
Synthesis Reference(s)The Journal of Organic Chemistry, 22, p. 713, 1957 DOI: 10.1021/jo01357a621
Flammability and ExplosibilityFlammable
Piperacillin Piperazine-N,N'-bis-(2-ethanesulphonic acid) dipotassium salt 1-(3-HYDROXYPROPYL)-4-METHYLPIPERAZINE Levodropropizine Trifluoperazine dihydrochloride 2-Ethylpiperazine N-Aminoethylpiperazine 1,4-BIS(2-HYDROXYETHYL)PIPERAZINE 1-Methylpiperazine 1-(2-(3-Pyridylmethylamino)ethyl)piperazine HEPES Piperazine 1-(4-Chlorobenzhydryl)piperazine 1-Ethylpiperazine 1,4-Bis(3-aminopropyl)piperazine 1-(3-AMINOPROPYL)-4-METHYLPIPERAZINE Triethylenediamine EPPS

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