| Description | Chlorophacinone is produced by condensation of 1-
phenyl-1-(4-chlorophenyl) acetone with dimethyl phthalate
in the presence of sodium methoxide (31).
This compound was introduced in 1961 and is now
widely used in Europe, the United States, and elsewhere.
It is used in baits against norway rats at a concentration
of 0.005–0.01%. Bait containing 0.025% chlorophacinone
gave a complete kill of house mice after a 7-d feeding
period but, in other tests, survivors were recorded following
10 and 21 days of feeding (5). Chlorophacinone acts as
an uncoupler of oxidative phosphorylation as well as an
anticoagulant (32), which is unusual among this group of
compounds. |
| Chemical Properties | Chlorophacinone is a highly toxic crystalline
solid. |
| Uses | Anticoagulant rodenticide. |
| Uses | Chlorophacinone (CPN) is an anticoagulant rodenticide widely used to control rodent infestations. |
| Definition | ChEBI: Chlorophacinone is a diarylmethane and a beta-triketone. |
| General Description | Crystals. Commercially available as oil concentrate and as dust concentrate. Used as an anticoagulant rodenticide. Chronic acting, multiple dose rodenticide. |
| Air & Water Reactions | Insoluble in water. |
| Reactivity Profile | Fire may produce irritating or poisonous gases. |
| Health Hazard | Chlorphacinon is highly toxic orally and by skin absorption. The probable oral lethal dose for humans is less than 5 mg/kg to 50 mg/kg, or between a taste (less than 7 drops) and 1 teaspoonful for a 150 lb. (70 kg) person. |
| Health Hazard | Highly toxic anticoagulant rodenticide; lowchlorine content but highly toxic; exhibitsacute, delayed, and chronic poisoning;symptoms include bleeding of nose andgum, blood in cough, urine, and stool,abdominal pain and hemorrhage; can beabsorbed through skin causing systemicpoisoning; ingestion of 1–2 g is estimatedto be fatal dose for adult human; U.S. EPAlisted extremely hazardous substance.
LD50 oral (rat): ～2 mg/kg
LD50 oral (mouse): ～1 mg/kg
LD50 oral (rabbit): 50 mg/kg
LD50 skin (rabbit): 200 mg/kg. |
| Fire Hazard | (Non-Specific -- Coumarin Derivative Pesticide, Solid, n.o.s.) Fire may produce irriating or poisonous gases. Runoff from fire control water may give off poisonous gases. Runoff from fire control or dilution water may cause pollution. When heated Chlorphacinon emits toxic fumes of chlorides. |
| Agricultural Uses | Rodenticide: This material is an anticoagulant rodenticide used around livestock and also on crops such as artichokes. Some brands are labeled for use indoors and outdoors for the control of mice, rats, moles, muskrats, voles and vampire
bats. Not approved for use in EU countries. Registered for use in the U.S. There are 24 global suppliers. |
| Trade name | AFNOR®; CAID®; DELTA®; DRAT RAT BAIT®; ENDORATS®; LIPHADIONE®; LM 91®; MICROZUL®; MURIOL®; PARTOX®[C]; QUICK®; RAMUCIDE®; RANAC®; RATOMET®; RAVIAC®; ROZOL®[C]; TOPITOX® |
| Safety Profile | Poison by ingestion and
skin contact. Human systemic effects by
ingestion: vascular changes. A pesticide. When heated to decomposition it emits
toxic fumes of Cl-. |
| Potential Exposure | Agricultural Chemical. This material
is an anticoagulant rodenticide. A potential danger to those
involved in its manufacture, formulation, and application
are at risk. |
| Shipping | UN3027 Coumarin derivative pesticides, solid,
toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. |
| Waste Disposal | Incineration at high temperature with effluent gas scrubbing.
|
