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| | Naftopidil dihydrochloride Basic information |
| Product Name: | Naftopidil dihydrochloride | | Synonyms: | (+-)-1-(4-(2-methoxyphenyl)piperazinyl)-3-(1-naphthyloxy)propan-2-ol;4-(2-methoxyphenyl)-alpha-((1-naphthalenyloxy)methyl)-1-pioerazineethano;4-(2-methoxyphenyl)-alpha-((1-naphthalenyloxy)methyl)-1-pioerazineethanol;kt-611;NAFTOPIDIL DIHYDROCHLORIDE (KT-611) A1 A DRENOCEPTOR ANTAG;NAFTOPIDIL;NafTopIDi1;4-(2-Methoxyphenyl)-alpha-[(1-naphthalenyloxy)methyl]-1-piperazineethanol dihydrochloride | | CAS: | 57149-07-2 | | MF: | C24H28N2O3 | | MW: | 392.49 | | EINECS: | 692-531-5 | | Product Categories: | AVISHOT;Intermediates & Fine Chemicals;Pharmaceuticals;Adrenoceptor | | Mol File: | 57149-07-2.mol |  |
| | Naftopidil dihydrochloride Chemical Properties |
| Melting point | 127 °C | | Boiling point | 517.2°C (rough estimate) | | density | 1.1592 (rough estimate) | | refractive index | 1.6300 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | solubility | methanol: >10 mg/mL | | form | solid | | pka | 14.01±0.20(Predicted) | | color | white | | Merck | 14,6356 | | CAS DataBase Reference | 57149-07-2(CAS DataBase Reference) |
| RIDADR | 3077 | | WGK Germany | 3 | | RTECS | TL9336500 | | HS Code | 29335990 | | Toxicity | LD50 in mice, rats (g/kg): 1.3, 6.4 orally (Himmel) |
| | Naftopidil dihydrochloride Usage And Synthesis |
| Description | Naftopidil was launched in Japan for the treatment of dysuria
associated with benign prostatic hypertrophy (BPH). It can be prepared by a two
step route starting with α-naphthol. Naftopidil is a potent postsynaptic-selective
alpha-l-antagonist with a slightly higher affinity for the human prostatic than for
the aortic alpha-adrenoceptor. It also shows a 5-HT1A agonistic effect, as well
as a weak calcium antagonistic activity, but no alpha-2 or beta-adrenoreceptor
affinity. In experiments with rats or rabbits, Naftopidil was shown to be more
potent and selective for the urodynamic effect than the hypotensive effect.
Aromatic or aliphatic hydroxylation are the major routes of metabolism,
producing metabolites with a profile similar to the parent compound. | | Chemical Properties | Off-White Solid | | Originator | Boehringer Mannheim (Germany) | | Uses | A α-1-Adrenergic receptor antagonist, antihypertensive. | | Uses | Naftopidil is an α-1-adrenergic receptor antagonist. Naftopidil is used as an antihypertensive. | | Uses | antihypertensive, alpha-blocker, 5HT1a agonist | | Definition | ChEBI: Naftopidil is a member of piperazines. | | Brand name | Avishot;Flivas | | Biological Activity | An α 1 -adrenoceptor antagonist with only weak antagonism at post-junctional α 2 receptors; a potent, persistent antihypertensive and vasodilator. |
| | Naftopidil dihydrochloride Preparation Products And Raw materials |
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