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| | BETA-NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE SODIUM SALT Basic information |
| | BETA-NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE SODIUM SALT Chemical Properties |
| Melting point | 175-178 °C (dec.)(lit.) | | storage temp. | -20°C | | solubility | H2O: 50 mg/mL | | form | powder | | color | off-white to yellow | | Water Solubility | Soluble in water. | | Merck | 14,6344 | | BRN | 4779954 | | InChIKey | JNUMDLCHLVUHFS-QYZPTAICSA-M |
| | BETA-NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE SODIUM SALT Usage And Synthesis |
| Description | The nicotinamide adenine dinucleotide phosphate oxidase（NADP）is a multicomponent system that transfers an electron to molecular oxygen by way of FAD and heme to form superoxide (O2?) .Cytochrome b558 is a membrane-bound heterodimer lodged in the wall of the secondary granules; the large glycosylated β subunit is gp91phox and the small nonglycosylated α subunit is p22phox.The cytoplasmic tail of gp91phox binds FAD, heme, and NADPH, which are required for electron transfer to oxygen (O2).Neutrophil stimulation leads to aggregation and phosphorylation of p47phox, p67phox, p40phox, and the small guanosine triphosphate (GTP)–binding proteins RAC1/RAC2, which dock with the cytochrome at the membrane through binding of p47phox and p22phox. | | Description | Nicotinamide adenine dinucleotide phosphate, abbreviated NADP+ or, in older notation, TPN (triphosphopyridine nucleotide), is a cofactor used in anabolic reactions, such as the Calvin cycle and lipid and nucleic acid syntheses, which require NADPH as a reducing agent ('hydrogen source').It is used by all forms of cellular life. | | Chemical Properties | White to slightly yellowish powder | | Uses | β-Nicotinamide adenine dinucleotide 2′-phosphate (NADP+) and β-Nicotinamide adenine dinucleotide 2′-phosphate, reduced (NADPH) comprise a coenzyme redox pair (NADP+:NADPH) involved in a wide range of enzyme catalyzed oxidation reduction reactions.
β-Nicotinamide Adenine Dinucleotide Phosphate Sodium Salt Hydrate is a substrate NADP which plays a role in a variety of metabolic processes. | | Uses | β-Nicotinamide adenine dinucleotide phosphate monosodium salt acts as an electron acceptor used by cells. It is also useful in vitro to study NADP. Furthermore, it is used in a wide range of enzyme catalyzed oxidation reduction reactions. The combination of NADP+/NADPH is employed in a variety of antioxidation mechanisms, which protect against reactive oxidation species accumulation. | | Biosynthesis | In general, NADP+ is synthesized before NADPH is. Such a reaction usually starts with NAD+ from either the de-novo or the salvage pathway, with NAD+ kinase adding the extra phosphate group. ADP-ribosyl cyclase allows for synthesis from nicotinamide in the salvage pathway, and NADP+ phosphatase can convert NADPH back to NADH to maintain a balance.Some forms of the NAD+ kinase, notably the one in mitochondria, can also accept NADH to turn it directly into NADPH.[3][4] The prokaryotic pathway is less well understood, but with all the similar proteins the process should work in a similar way. | | Biochem/physiol Actions | Electron acceptor |
| | BETA-NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE SODIUM SALT Preparation Products And Raw materials |
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