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| | Sitagliptin Impurity 10 Basic information |
| Product Name: | Sitagliptin Impurity 10 | | Synonyms: | Sitagliptin-8;Sitagliptin Hydroxy Amide Impurity;Sitagliptin impurity 41/Sitagliptin Hydroxy Amide Impurity/3-hydroxy-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo [4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one;3-hydroxy-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo [4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one;1-Butanone, 1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-3-hydroxy-4-(2,4,5-trifluorophenyl)-;(R/S)-3-hydroxy-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one;1-[5,6-Dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-3-hydroxy-4-(2,4,5-trifluo;Sitagliptin phosphate impurity 6 | | CAS: | 1253056-01-7 | | MF: | C16H14F6N4O2 | | MW: | 408.3 | | EINECS: | | | Product Categories: | | | Mol File: | 1253056-01-7.mol |  |
| | Sitagliptin Impurity 10 Chemical Properties |
| Boiling point | 542.2±60.0 °C(Predicted) | | density | 1.61±0.1 g/cm3(Predicted) | | solubility | Chloroform (Slightly), Methanol (Slightly) | | form | Solid | | pka | 13.69±0.20(Predicted) | | color | White to Off-White |
| | Sitagliptin Impurity 10 Usage And Synthesis |
| Uses | 1-[5,6-Dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-3-hydroxy-4-(2,4,5-trifluorophenyl)-1-butanone is an intermediate in the synthesis of 3-Desamino-2,3-dehydro Sitagliptin (D281985), which is an impurity of Sitagliptin (S491000); a trizolopyrazine dipeptidyl peptidase IV inhibitor. Sitagliptin has recently been approved for the therapy of type II diabetes. |
| | Sitagliptin Impurity 10 Preparation Products And Raw materials |
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