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| | Urapidil hydrochloride Basic information |
| Product Name: | Urapidil hydrochloride | | Synonyms: | 6[[3-[4-(O-METHOXYPHENYL)-1-PIPERAZINYL]PROPYL]AMINO]-1,3-DIMETHYLURACIL HYDROCHLORIDE;6-[[3-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]PROPYL]AMINO]-1,3-DIMETHYL-2,4(1H,3H)-PYRIMIDINEDIONE;6-[[3-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]PROPYL]AMINO]-1,3-DIMETHYL-2,4(1H,3H)-PYRIMIDINEDIONE HYDROCHLORIDE;URAPIDIL HCL;URAPIDIL HYDROCHLORIDE;URAPIDIL HYDROCHLORIDE A1 ADRENOCEPTOR A NTAG;6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,3-dimethyl-pyrimidine-2,4-dione hydrochloride;6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,3-dimethylpyrimidine-2,4-dione hydrochloride | | CAS: | 64887-14-5 | | MF: | C20H30ClN5O3 | | MW: | 423.94 | | EINECS: | 636-348-0 | | Product Categories: | Adrenoceptor;Intermediates & Fine Chemicals;Pharmaceuticals;64887-14-5 | | Mol File: | 64887-14-5.mol |  |
| | Urapidil hydrochloride Chemical Properties |
| Melting point | 156-1580C | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | H2O: soluble | | form | solid | | color | white | | Water Solubility | Soluble to 50 mM in water |
| Hazard Codes | Xn | | Risk Statements | 22-36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | RTECS | YQ9862000 |
| | Urapidil hydrochloride Usage And Synthesis |
| Description | Urapidil is an antagonist of α1-adrenergic receptors (α1-ARs) and a partial agonist of the serotonin (5-HT) receptor subtype 5-HT1A. It selectively binds to α1- over α2-ARs (IC50s = 0.74 and 42 μM, respectively) and to 5-HT1A over 5-HT1B and 5-HT2 receptors (IC50s = 0.4, 20.4, and >10 μM, respectively) in rat cortex. Urapidil inhibits cAMP accumulation induced by forskolin in calf hippocampus as a functional model for 5-HT1A receptors (EC50 = 390 nM). It is also a β1-AR antagonist that inhibits the positive chronotropic response induced by isoproterenol in isolated rat atria (pA2 = 6.05). Urapidil (1 μmol/kg, i.v.) lowers mean arterial pressure (MAP) in anesthetized cats, an effect that is reduced by central administration of the 5-HT1A receptor antagonist spiroxatrine. | | Chemical Properties | White to Off-White Crystalline Powder | | Uses | α1-Adrenergic antagonist; derivative of Uracil (U801000). Antihypertensive. | | Uses | Antihypertensive;Serotonergic receptor agonist | | Uses | a1-Adrenergic antagonist; derivative of Uracil. Antihypertensive | | Biological Activity | α 1 -adrenoceptor antagonist and 5-HT 1A receptor agonist (pIC 50 values are 6.13 and 6.4 respectively). Clinically used hypotensive agent. |
| | Urapidil hydrochloride Preparation Products And Raw materials |
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