ChemicalBook Product Catalog Analytical Chemistry Standard Pharmaceutical Impurity Reference Standards 3-(trifluoromethyl)-6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one

3-(trifluoromethyl)-6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one

3-(trifluoromethyl)-6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one Basic information
Product Name:3-(trifluoromethyl)-6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one
Synonyms:3-(trifluoromethyl)-6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;1,2,4-Triazolo[4,3-a]pyrazin-8(5H)-one, 6,7-dihydro-3-(trifluoromethyl)-;Sitagliptin Impurity 114;3-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3- a]pyrazin-8-one;3-(trifluoromethyl)-6,7-dihydro-[l,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;3-(trifluoromethyl)-6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one? (Sitagliptin Impurity）
CAS:877402-45-4
MF:C6H5F3N4O
MW:206.13
EINECS:
Product Categories:
Mol File:877402-45-4.mol
3-(trifluoromethyl)-6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one Structure
3-(trifluoromethyl)-6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one Chemical Properties
density 1.90±0.1 g/cm3(Predicted)
solubility DMSO (Slightly), Methanol (Slightly)
pka12.69±0.20(Predicted)
form Solid
color Off-White to Light Grey
Safety Information
MSDS Information
3-(trifluoromethyl)-6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one Usage And Synthesis
Uses3-(Trifluoromethyl)-6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one is an intermediate in the synthesis of Sitagliptin Triazecine Analog (S491015). Sitagliptin Triazecine Analog is related to the family of Sitagliptin compounds which has recently been approved for the therapy of type II diabetes.
3-(trifluoromethyl)-6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one Preparation Products And Raw materials
Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate Sitagliptin Benzenebutanoicacid,b-[[(1,1-diMethylethoxy)carbonyl]aMino]-2,4,5-trifluoro-,Methylester,(bR)- (R)-methyl 3-acetamido-4-(2,4,5-trifluorophenyl)butanoate Sitagliptin Impurity 34 2-CHLOROMETHYL-5-TRIFLUOROMETHYL-[1,3,4]OXADIAZOLE ethyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate Methyl 3-aMino-4-(2,4,5-trifluorophenyl)butanoate Sitagliptin impurity 5 Sitagliptin Impurity 77 Sitagliptin Impurity 46 Sitagliptin Impurity 28 2-Pentafluorophenyl-malonic acid diethyl ester 2,2,2-TRIFLUORO-N'-(TRIFLUOROACETYL)ACETOHYDRAZIDE (S)-Sitagliptin Phosphate Sitagliptin DeaMino IMpurity 1 Sitagliptin Defuoro IMpurity 5 Sitagliptin Impurity 14
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